Clinical Ocular Toxicology: Drug-Induced Ocular Side Effects

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Written by international authorities in ocular toxicology, including the Founder of The National Registry of Drug-Induced Side Effects and its current Director, this essential resource provides the clinically relevant information you need to effectively diagnose and manage herbal, chemical, and drug-related ocular problems. Comprehensive coverage of all drugs’ generic and trade drug names, primary uses, ocular and systemic side effects, and clinical significance make this book - like its best-selling predecessor, Drug-Induced Ocular Side Effects - the ideal reference for quick, on-the-spot consultation.

• Leaders in the field provide need-to-know information on all aspects of ocular toxicology—all in one concise reference.

• Data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden) help you recognize and avoid drug-induced ocular side effects.

• A highly templated format makes retrieval of essential knowledge quick and easy.

• A wealth of full-color photographs provide vivid, visual diagnostic guidance.

• The latest information on approved medications helps you stay up to date and provide state-of-the-art care.

• Extensive coverage of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics gives you the knowledge you need to manage any challenge in ocular toxicology

• Authoritative guidance on ocular drugs and their use in pregnancy helps you safely manage the unique needs of these patients.

• The inclusion of the WHO classification system helps you determine whether a particular side effect is certain, probable, or likely to occur.

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Editorial Reviews

From the Publisher
The book is targeted at "busy clinicians." This book stands alone in presenting a systematic review of ocular side effects of medications. It is a high quality publication that will be a valuable reference for ophthalmologists. — DOODY'S BOOK REVIEW, 3 Stars ***
Doody's Review Service
Reviewer: Paul Hahn, MD, PhD (University of Pennsylvania School of Medicine)
Description: This is a review of the ocular side effects of a comprehensive subset of medications, chemicals, and herbals/supplements.
Purpose: According to the authors, the book is intended as a guide to help clinicians decide whether a visual problem is related to a chemical or medication. I am not aware of any other books that address a similar goal. Medications can have a variety of ocular side effects, and a comprehensive guide listing possible side effects is a valuable reference in clinical practice.
Audience: The book is targeted at "busy clinicians." It is certainly a valuable reference for ophthalmologists who wish to determine whether a patient's symptoms may be a lesser known side effect of a patient's medications (either ocular or systemic). It is also particularly helpful for residents or students who may not be as familiar as experienced clinicians with medication-induced side effects.
Features: Basic pharmacologic principles, including drug delivery/toxicology and clinical methods for evaluating toxic ophthalmic side effects, begin the book. The main part of the book is composed of a list of medications organized by medication type (e.g.: anti-infectives, CNS drugs, GI agents, etc). For each entry, the use of the medication is described, followed by a list of ocular side effects ranked by certainty, a short paragraph describing the clinical relevance of the side effects, followed by references and further readings. The strength of the book lies in this list of ocular side effects for each medication. The breadth of medications covered is comprehensive and includes toxic chemicals and even herbals/supplements. The book is particularly valuable as a clinical reference, and the index is extremely helpful. The index lists all the medications in a standard index format, but it also lists common ocular side effects with their associated medications, color-coded by certainty of association. This book is intended for clinicians who are trying to determine if ocular symptoms may be medication related, making this index is extremely valuable.
Assessment: This book stands alone (as far as I know) in presenting a systematic review of ocular side effects of medications. It is a high quality publication that will be a valuable reference for ophthalmologists.
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Product Details

  • ISBN-13: 9781416046738
  • Publisher: Elsevier Health Sciences
  • Publication date: 9/19/2008
  • Pages: 384
  • Product dimensions: 8.80 (w) x 10.90 (h) x 1.00 (d)

Meet the Author

Table of Contents

Instructions to Users

1 Principles of Therapy, Focke Ziemssen, MD, Manfred Zierhut, MD

2 Ocular Drug Delivery and Ocular Toxicology, Frederick T. “Fritz” Fraunfelder, MD

3 Methods to Evaluate Drug-Induced Visual Side Effects, Wiley A. Chambers, MD

4 Electrophysiology testing in Ocular Toxicology, Eberhart Zrenner, MD

5 National Registry of Drug-Induced Ocular Side Effects, Frederick W. “Rick” Fraunfelder, MD, Frederick T. “Fritz” Fraunfelder, MD

6 Herbal Medicines and Dietary Supplements - An Overview Frederick W. “Rick” Fraunfelder, MD

7 Drug-Induced Ocular Side Effects

Section 1 – Anti-Infectives

* AIDS-Related Agents
• Amebicides
• Antihelmintics
• Antibiotics
• Antifungal Agents
• Antileprosy Agents
• Antimalarial Agents
• Antiprotozoal Agents
• Antitubercular Agents

Section 2 – Agents Affecting the Central Nervous System

* Analeptics
• Anorexiants
• Antianxiety Agents
• Anticonvulsants
• Antidepressants
• Antipsychotic Agents
• Psychedelic Agents
• Sedatives and Hypnotics

Section 3 – Analgesics, Narcotic Antagonists, and Agents Used to Treat Arthritis

* Agents Used to Treat Gout
• Antirheumatic Agents
• Mild Analgesics
• Narcotic Antagonists* Strong Analgesics

Section 4 – Agents Used in Anesthesia

* Adjuncts to Anesthesia
• General Anesthesia* Local Anesthetics
• Therapeutic Gases

Section 5 – Gastrointestinal Agents

* Agents Used to Treat Acid Peptic Disorders
• Antacids
• Antiemetics
• Antilipidemic Agents
• Antispasmodics
• Gastrointestinal and Urinary Tract Stimulants

Section 6 – Cardiac, Vascular and Renal Agents

* Agents Used to Treat Migraine
• Antianginal Agents
• Antiarrythmic Agents
• Antihypertensive Agents
• Bronchodilators
• Diuretics
• Osmotics
• Peripheral Vasodilators
• Vasopressors

Section 7 – Hormones and Agents Affecting Hormonal Mechanisms

* Adrenal Corticosteroids
• Androgens
• Antithyroid Agents
• Erectile Dysfunction Agents
• Estrogens and Progestogens
• Ovulatory Agents
• Thyroid Hormones

Section 8 – Agents Affecting Blood Formation and Coagulability

* Agents Used to Treat Deficiency Anemias
• Anticoagulants
• Blood Substitutes

Section 9 – Homeostatic Agents

* Agents Used to Treat Hyperglycemia

Section 10 – Agents Used to Treat Allergic and Neuromuscular Disorders

* Agents Used to Treat Myasthenia Gravis
• Antihistamines
• Antiparkinsonism Agents
• Cholinesterase Reactivators
• Muscle Relaxants

Section 11 – Oncolytic Agents

* Antineoplastic Agents

Section 12 – Heavy Metal Antagonists and Miscellaneous Agents

* Agents Used to Treat Alcoholism
• Calcium Regulating Agents
• Chelating Agents
• Diagnostic Aids
• Immunosuppressants
• Retinoids
• Solvents
• Vaccines

Section 13 – Drugs Used in Ophthalmology

* Agents Used to Treat Age-Related Macular Degeneration
• Agents Used to Treat Allergies
• Agents Used to Treat Glaucoma
• Antiviral Agents
• Carbonic Anhydrase Inhibitors
• Decongestants
• Mydriatics and Cycloplegics
• Neurotoxins
• Ophthalmic Dyes
• Ophthalmic Implants
• Ophthalmic Preservatives and Antiseptics
• Proteolytic Enzymes
• Topical Local Anesthetics
• Topical Ocular Nonsteroidal Anti-Inflammatory Drugs
• Topical Osmotic Agents
• Viscoelastics

8 Chemical-Induced Ocular Side Effects, Devin Gattey, MD

* Acids
• Aerosals
• Alcohols
• Alkali
• Bleaches
• Detergents
• Glues
• Herbicides and Insecticides
• Hydrocarbons
• Miscellaneous

9 Herbal Medicines and Dietary Supplement-Induced Ocular Side Effects

10 Index of Side Effects

11 Index of Drug Names

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