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Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.
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Describes therapeutic regimens/physiologic concepts & kinetics/pharmacologic response/dialysis/etc.
|Definitions of Symbols|
|1||Why Clinical Pharmacokinetics?||1|
|5||Therapeutic Response and Toxicity||53|
|8||Movement Through Membranes||109|
|12||Integration With Kinetics||184|
|15||Age and Weight||230|
|22||Dose and Time Dependencies||394|
|Appendix I. Additional Concepts and Derivations||469|
|Appendix II. Answers to Problems||507|
Posted April 8, 2001
Prof Rowland is undoubtedly an expert in the field of pharmacokinetics (PK). I was somewhat surprised that this book represented a marginal improvement from its previous version. This book is particularly useful for somebody who wants basic exposure to clinical aspects of PK, for whom mathematical oriented PK (books by Wagner, Gibaldi, or Sheiner) is monumental for comprehension and/or application. Furthermore, this book is an academic presentation of basic PK concepts. If somebody is interested in core clinical PK, currently there is no book in this area (a reasonably good book, however, is Applied PK - Evans et al). Rowland's book can be substantially improved by including clinical PK issues commonly encountered in drug development in the industry. Otherwise, a good starter book for those interested in understanding basic concepts of PK in a clinical academic setting.Was this review helpful? Yes NoThank you for your feedback. Report this reviewThank you, this review has been flagged.
Posted June 13, 2000
This book is one of the best known in the filed of clinical pharmacokinetics. All the information is there, with good diagrams. However, I found the text often difficult to follow, with some gaps in explanation of stated facts. Also, the information in the appendices would be better off incorporated into the main text. The answers to the problems are often simply stated without an explanation, and therefore an educational opportunity is lost. All in all, this book has all the facts and I have learned a lot from reading it, but it requires a lot of effort to read, at least from a clinician-investigator point of view.Was this review helpful? Yes NoThank you for your feedback. Report this reviewThank you, this review has been flagged.