Clinical Pharmacokinetics: Concepts and Applications / Edition 3

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Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.

BlackBerry® OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile™ Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Describes therapeutic regimens/physiologic concepts & kinetics/pharmacologic response/dialysis/etc.

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Editorial Reviews

Second edition of a primer on pharmacokinetics with clinical applications. Each chapter has a stated set of objectives, identifying the major aspects to be learned, and a series of problems, allowing the reader to test his or her understanding of the material. No bibliography. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780683074048
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 10/28/1995
  • Edition description: Third Edition
  • Edition number: 3
  • Pages: 608
  • Product dimensions: 8.58 (w) x 8.80 (h) x 1.04 (d)

Table of Contents

Definitions of Symbols
1 Why Clinical Pharmacokinetics? 1
2 Basic Considerations 11
3 Intravenous Dose 18
4 Extravascular Dose 34
5 Therapeutic Response and Toxicity 53
6 Constant-Rate Regimens 66
7 Multiple-Dose Regimens 83
8 Movement Through Membranes 109
9 Absorption 119
10 Distribution 137
11 Elimination 156
12 Integration With Kinetics 184
13 Variability 203
14 Genetics 220
15 Age and Weight 230
16 Disease 248
17 Interacting Drugs 267
18 Concentration Monitoring 290
19 Distribution Kinetics 313
20 Pharmacologic Response 340
21 Metabolite Kinetics 367
22 Dose and Time Dependencies 394
23 Turnover Concepts 424
24 Dialysis 443
Selected Reading 463
Appendix I. Additional Concepts and Derivations 469
Appendix II. Answers to Problems 507
Index 586
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  • Anonymous

    Posted April 8, 2001

    Excellent and informative, minor upgrade from previous edition

    Prof Rowland is undoubtedly an expert in the field of pharmacokinetics (PK). I was somewhat surprised that this book represented a marginal improvement from its previous version. This book is particularly useful for somebody who wants basic exposure to clinical aspects of PK, for whom mathematical oriented PK (books by Wagner, Gibaldi, or Sheiner) is monumental for comprehension and/or application. Furthermore, this book is an academic presentation of basic PK concepts. If somebody is interested in core clinical PK, currently there is no book in this area (a reasonably good book, however, is Applied PK - Evans et al). Rowland's book can be substantially improved by including clinical PK issues commonly encountered in drug development in the industry. Otherwise, a good starter book for those interested in understanding basic concepts of PK in a clinical academic setting.

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  • Anonymous

    Posted June 13, 2000

    Good content, but hard reading

    This book is one of the best known in the filed of clinical pharmacokinetics. All the information is there, with good diagrams. However, I found the text often difficult to follow, with some gaps in explanation of stated facts. Also, the information in the appendices would be better off incorporated into the main text. The answers to the problems are often simply stated without an explanation, and therefore an educational opportunity is lost. All in all, this book has all the facts and I have learned a lot from reading it, but it requires a lot of effort to read, at least from a clinician-investigator point of view.

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