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Doody's Review ServiceReviewer: Manjunath (Amit) Pai, PharmD (University of Illinois at Chicago College of Pharmacy)
Description: This second edition of the clinical pharmacokinetics pocket reference updates the original edition published in 1997 with information on new drugs and monitoring parameters.
Purpose: The purpose is to provide easily accessible information on initiating and monitoring drug therapy. The book is designed to estimate drug doses, predict drug concentrations, and describe the impact of drug interactions.
Audience: It is targeted toward students on clinical rotations in cardiology, infectious diseases, neurology, psychiatry, internal medicine, and transplantation. It has also been written for general medicine and specialty clinicians.
Features: General pharmacokinetic principles are introduced, followed by specific drug and drug class related parameters. The suggested sampling times, therapeutic range, concentration related efficacy, and toxicity are provided. The impact of drug and disease state interactions is included but not discussed in sufficient detail. A chapter on rational use of drug concentrations provides a step-by-step method of evaluating the need for therapeutic drug monitoring. Concise information on drug dosing in neonates and pediatric and geriatric patients is also included. An appendix of the therapeutic ranges of drugs in traditional and SI units is provided but it does not contain all of the drugs covered in the chapters.
Assessment: This is an excellent resource of pharmacokinetic information for students and clinicians that includes dosing in pediatric patients, estimating creatinine clearance, and interpretation and use of drug concentration measurements. The reference meets most of its objectives but does not consistently provide sufficient information in the drug interaction sections to predict the degree of dosage adjustment. In addition, it contains information that can be obtained from larger but more concise sources such as Lacy's Drug Information Handbook 2000-2001, 8th Edition (Lexi-Comp, 2001). Furthermore, it has been designed to fit in the pocket of a laboratory coat but weighs over a pound, which may detract from its usefulness as a true pocket reference.