Clinical Pharmacology / Edition 11

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A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy.

  • Introductory first three sections cover general principles of clinical pharmacology; five subsequent sections cover drug treatment of disease, organised by body system
  • Retains the highly approachable style set by the original author, Professor Laurence and appreciated by generations of readers
  • Emphasis throughout is on evidence-based and safe drug prescribing
  • The International Advisory Board ensures content reflects the needs of the developing world.
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Editorial Reviews

Doody's Review Service
Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: D. R. Laurence authored the first edition of Clinical Pharmacology in 1960. This 9th edition is the first one of which he is not an author or co-author, although he has written a short "farewell." The style of writing sets this book apart from other textbooks in clinical pharmacology, making reading more enjoyable. On the other hand, other books may provide more concise explanations when used as a reference. Although only two authors have written this edition, experts in the field have extensively reviewed each chapter. The book provides comprehensive coverage of clinical pharmacology. Since this is a British publication, the U.S. reader will find different drugs and spellings than they are used to.
Purpose: The long life of this book attests to its value. It is written with the idea that physicians prescribe drugs that are very different from those that they studied as students. The book is written to be understandable by the practitioner as well as the expert in pharmacology. The book is very enjoyable to read but yet addresses the important things that a physician needs to know to practice evidence-based medicine in the 21st century.
Audience: This book is primarily written for doctors who prescribe drugs, but this book would be excellent for the student in clinical training and should also be of great value to residents and both general and specialist practitioners. Since the drugs used in Great Britain are sometimes different than those used in the United States, the American reader will find discrepancies from accepted practice in the U.S.
Features: The first section of this book deals with general issues including discovery, testing, and regulation of drug use in humans. The second section of this book deals the general principles of pharmacology including pharmacokinetics, pharmacodynamics, and toxicity. The remaining sections of the book discuss the use of drugs broken down into the areas of infection and inflammation, nervous system, cardiorespiratory and renal systems, blood and neoplastic disease, gastrointestinal system, and endocrine system, metabolic conditions. Each chapter begins with a box that provides a concise synopsis. Within each chapter there are high-yield summary boxes, tables, figures and algorithms for the management of selected diseases.
Assessment: The British reader who is interested in clinical pharmacology has two excellent textbooks to choose from. I would recommend this one for those who want to read the entire chapter devoted to a topic, but for those who wish to use a book as a reference, the third edition of the Oxford Textbook of Clinical Pharmacology and Drug Therapy by Grahame-Smith and Aronson (Oxford University Press, 2002), may be more useful. The U.S. reader may prefer the fourth edition of Melmon and Morrelli's Clinical Pharmacology by Carruthers et al. (McGraw-Hill, 2000) . For the reader interested in the basic principles of clinical pharmacology, Principles of Clinical Pharmacology by Atkinson et al. (Academic Press, 2001) is an excellent choice.
From the Publisher
"...therapeutics is a field which rapidly and regularly is important to have an authoritative reference source handy. This could easily be it and with the added bonus of being highly readable, the ninth edition continues the lineage of its illustrious predecessors. An excellent addition to the bookshelf." Dr Harry Brown, Medix-UK, May 2003
to it for interesting description of drugs, their actions, interactions, side effects and anything else required in the clinical years of a medical degree." 3rd Year Medical Student, September 2003

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780702040849
  • Publisher: Elsevier Health Sciences
  • Publication date: 8/21/2012
  • Edition description: 11
  • Edition number: 11
  • Pages: 680
  • Product dimensions: 7.40 (w) x 9.70 (h) x 1.20 (d)

Table of Contents

Section 1 General. Clinical pharmacology. Topics in drug therapy. Discovery and development of drugs. Evaluation of drugs in humans. Official regulation of medicines. Classification of drugs and naming of drugs. Section 2 From Pharmacology to Toxicology. General pharmacology. Unwanted effects of drugs: adverse reactions. Poisoning, drug overdose, antidotes. Drug abuse. Section 3 Infection and Inflammation.. Chemotherapy of infections. Antibacterial drugs. Chemotherapy of bacterial infections. Viral, fungal, protozoal and helminthis infections. Drugs for inflammation and rheumatological disease. Drugs and the skin. Section 4 Nervous System. Pain and analgesics. Anaesthesia and neuromuscular block. Psycotropic drugs.Epilepsy, parkinsonism and allied conditions. Section 5 Cardiorespiratory and Renal Systems. Cholinergic and antimuscarinic (anticholinergic) mechanisms anddrugs. Adrenergic mechanisms and drugs. Arterial hypertension, angina pectoris, myocardial infarction. Cardiac arrhythmia andheart failure. Hyperlipidaemias. Kidney and urinary tract. Respiratory system. Section 6 Blood and Neoplastic Disease. Drugs and haemostasis. Cellular disorders and anaemias. Neoplastic disease and immunosuppression. Section 7 Gastrointestinal System. Oesophagus, stomach and duodenum. Intestines. Liver, biliary tract and pancreas. Section 8 Endocrine System, Metabolic Conditions. Adrenal corticosteroids, antagonists, corticotrophin. Diabetes mellitus, insulin, oral antidiabetic agents, obesity. Thyroid hormones, antithyroid drugs. Hypothalmic, pituitary and sex hormones. Vitamins, calcium, bone.
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