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Clinical Physiology of Acid-Base and Electrolyte Disorders / Edition 5

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“The core of information that the clinician should possess”

-- From the Preface

Like its highly acclaimed predecessors, the Fifth Edition of this classic effectively integrates the essentials of renal and electrolyte physiology with the common clinical disorders of acid-base and electrolyte balance.


*An easy-to-read writing style that demystifies this difficult subject

*Basic science coverage of water and electrolyte physiology, renal physiology, and regulation of water and electrolyte balance

*Clinical chapters that quickly guide you through key points of etiology, pathophysiology, symptoms, diagnosis, and treatment of common disorders

*Crystal clear figures and handy tables that summarize key information

*End-of-chapter problems that test mastery of the material


*New sections on endothelin and nitric oxide

*State-of-the-art information on the properties of the calcium-sensing receptor

*Revised and expanded coverage of the neurologic sequelae of hyponatremia

*In-depth discussion of the edematous states, including heart failure, nephrotic syndrome, and cirrhosis

*Hundreds of new references

The book contains black-and-white illustrations.

This superbly written text gives students, residents, and practitioners a unique advantage in understanding the mechanisms and clinical management of acid-base disorders. Presents the core information to understand renal and electrolyte physiology and reviews the treatment rationale for all major acid-base and electrolyte disturbances. New questions and answers are added to each chapter with significant updating to the entire text.

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Editorial Reviews

Largely rewritten to reflect advances that have been made and controversies that have arisen since publication of the 3rd edition in 1989, this monograph integrates the essentials of renal and electrolyte physiology with the common clinical disorders of acid-base and electrolyte balance. For students, residents, and clinicians. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780071346825
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 12/22/2000
  • Edition description: REV
  • Edition number: 5
  • Pages: 992
  • Sales rank: 696,186
  • Product dimensions: 6.30 (w) x 9.20 (h) x 1.38 (d)

Meet the Author

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

McGraw-Hill authors represent the leading experts in their fields and are dedicated to improving the lives, careers, and interests of readers worldwide

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Table of Contents

1 Introduction to Renal Function 3
2 Renal Circulation and Glomerular Filtration Rate 20
3 Proximal Tubule 66
4 Loop of Henle and the Countercurrent Mechanism 104
5 Functions of the Distal Nephron 132
6 Effects of Hormones on Renal Function 150
7 The Total Body Water and the Plasma Sodium Concentration 219
8 Regulation of the Effective Circulating Volume 235
9 Regulation of Plasma Osmolality 261
10 Acid-Base Physiology 274
11 Regulation of Acid-Base Balance 300
12 Potassium Homeostasis 346
13 Meaning and Application of Urine Chemistries 379
14 Hypovolemic States 388
15 Clinical Use of Diuretics 418
16 Edematous States 447
17 Introduction to Simple and Mixed Acid-Base Disorders 500
18 Metabolic Alkalosis 515
19 Metabolic Acidosis 540
20 Respiratory Acidosis 604
21 Respiratory Alkalosis 629
22 Introduction to Disorders of Osmolality 638
23 Hypoosmolal States - Hyponatremia 651
24 Hyperosmolal States - Hypernatremia 695
25 Hyperosmolal States - Hyperglycemia 737
26 Introduction to Disorders of Potassium Balance 763
27 Hypokalemia 776
28 Hyperkalemia 823
29 Answers to the Problems 863
30 Summary of Equations and Formulas 888
Index 893
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