Clinical Research in Diabetes and Obesity, Volume 1: Methods, Assessment, and Metabolic Regulation / Edition 1

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Overview

An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world. This volume critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Anthony Pick, MD (University of Chicago Medical Center)
Description: This is a comprehensive and current overview of the regulation of intermediary metabolism in diabetic and nondiabetic humans. The first section gives a critical assessment of the major clinical research techniques used and is followed by detailed reviews of their application.
Purpose: The purpose is to review, in an easily understood fashion, the advances and contributions of clinical research to understanding the pathophysiology of diabetes, written by experts in the field. These worthy objectives were met by the authors.
Audience: The book is written for students, fellows, researchers, and practitioners interested in clinical investigation. It will also be of interest and value to individuals involved in diabetes and metabolism research at all levels of focus. The authors are published experts in the field and are credible authorities.
Features: This attractive book contains black-and-white figures, tables, and graphs of suitable quality and quantity. The references are well chosen and current. The major strength of the book is the uniform high quality of the text itself.
Assessment: The book is of superb quality and does an admirable job of lucidly and succinctly conveying, in a state-of-the-art fashion, exceedingly complicated and important physiological and pathophysiological concepts and highlights the relevance, elegance, and excitement of world-class clinical research. The book is a worthy addition to bookstores and libraries. It is a "must have" for those interested in metabolism and metabolism-related clinical research and for those desiring a detailed understanding of the physiology of intermediary metabolism and the pathophysiology of diabetes.
From The Critics
Reviewer: Anthony Pick, MD(University of Chicago Medical Center)
Description: This is a comprehensive and current overview of the regulation of intermediary metabolism in diabetic and nondiabetic humans. The first section gives a critical assessment of the major clinical research techniques used and is followed by detailed reviews of their application.
Purpose: The purpose is to review, in an easily understood fashion, the advances and contributions of clinical research to understanding the pathophysiology of diabetes, written by experts in the field. These worthy objectives were met by the authors.
Audience: The book is written for students, fellows, researchers, and practitioners interested in clinical investigation. It will also be of interest and value to individuals involved in diabetes and metabolism research at all levels of focus. The authors are published experts in the field and are credible authorities.
Features: This attractive book contains black-and-white figures, tables, and graphs of suitable quality and quantity. The references are well chosen and current. The major strength of the book is the uniform high quality of the text itself.
Assessment: The book is of superb quality and does an admirable job of lucidly and succinctly conveying, in a state-of-the-art fashion, exceedingly complicated and important physiological and pathophysiological concepts and highlights the relevance, elegance, and excitement of world-class clinical research. The book is a worthy addition to bookstores and libraries. It is a "must have" for those interested in metabolism and metabolism-related clinical research and for those desiring a detailed understanding of the physiology of intermediary metabolism and the pathophysiology of diabetes.
Anthony Pick
This is a comprehensive and current overview of the regulation of intermediary metabolism in diabetic and nondiabetic humans. The first section gives a critical assessment of the major clinical research techniques used and is followed by detailed reviews of their application. The purpose is to review, in an easily understood fashion, the advances and contributions of clinical research to understanding the pathophysiology of diabetes, written by experts in the field. These worthy objectives were met by the authors. The book is written for students, fellows, researchers, and practitioners interested in clinical investigation. It will also be of interest and value to individuals involved in diabetes and metabolism research at all levels of focus. The authors are published experts in the field and are credible authorities. This attractive book contains black-and-white figures, tables, and graphs of suitable quality and quantity. The references are well chosen and current. The major strength of the book is the uniform high quality of the text itself. The book is of superb quality and does an admirable job of lucidly and succinctly conveying, in a state-of-the-art fashion, exceedingly complicated and important physiological and pathophysiological concepts and highlights the relevance, elegance, and excitement of world-class clinical research. The book is a worthy addition to bookstores and libraries. It is a "must have" for those interested in metabolism and metabolism-related clinical research and for those desiring a detailed understanding of the physiology of intermediary metabolism and the pathophysiology of diabetes.
Booknews
Reports on the latest advances in clinical research on diabetes and obesity, reviewing strengths and limitations of major research techniques and showing how those methods have been used to carry out studies on carbohydrate, lipid, and protein metabolism in the disease. Contains sections on research methods, effects of hormones on substrate metabolism, and postabsorptive and postprandial states in regulation of metabolism in humans. For researchers in diabetes, endocrinology, and lipidology, and physicians. Annotation c. by Book News, Inc., Portland, Or.
From the Publisher
This book is of superb quality and does an admirable job of lucidly and succinctly conveying...exceedingly complicated and important physiological and pathophysiological concepts.. A 'must have' for those interested in metabolism and metabolism-related clinical research. Four Stars! - Doody's Health Sciences Book Review Journal

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780896033504
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 10/2/2007
  • Series: Contemporary Biomedicine Series , #14
  • Edition description: 1997
  • Edition number: 1
  • Pages: 396
  • Product dimensions: 10.00 (w) x 7.00 (h) x 0.94 (d)

Table of Contents

Part I: Methods in Clinical Research. Assessment of B-Cell Function in Humans: Approach and Interpretation, Steven E. Kahn. In Vivo Measurement of Insulin Sensitivity in Humans, Masafumi Matsuda and Ralph A. DeFronzo. Insulin Action in Skeletal Muscle: In Vivo Assessment, Lawrence J. Mandarino. Glucose Effectiveness, Richard N. Bergman, Ta-Chen Ni, and Marilyn Ader. Assessment of Substrate and Energy Metabolism in Vivo, Keith N. Frayn and Ian A. Macdonald. Assessment of Free Fatty Acid Metabolism, Michael D. Jensen. Assessment of Protein Metabolism in Diabetes, K. Sreekumaran Nair. Assessment Methods of Carbohydrate Metabolism in the Liver (Glycogenolysis, Gluconeogenesis, and Glycogen Synthesis), Jerry Radziuk. Part II: Effect of Hormones on Substrate Metabolism. Insulin Effects on Substrate Metabolism, William G. Blankard and John N. Clore. The Metabolic Actions of Glucagon, Alan D. Cherrington. The Effects of Glucocorticoid Hormones on Substrate Metabolism, Sean F. Dinneen. The Role of Growth Hormone, Niels Møller, Hans Ørskov, and Ole Schmitz. Interrelationships Between the Central Nervous System and Peripheral Glucose Metabolism, Patrick J. Boyle. Part III: Regulation of Metabolism in Humans: Postabsorptive and Postprandial States. Regulation of Carbohydrate Metabolism, Roy Taylor and Gerald I. Shulman. Effects of Lipids on Blood Glucose Regulation and Insulin Action, Edward W. Kraegen, David G. P. Carey, and Lesley V. Campbell. Protein Metabolism in Healthy and Diabetic Humans, Eugene J. Barrett and David A. Fryburg. Regulation of Fuel Metabolism During Exercise, Amy E. Halseth, Pietro Galassetti, and David H. Wasserman. Glucose Counterregulation, John E. Gerich. Index.

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