Clinical Trials in Cardiovascular Disease: A Companion to Braunwald's Heart Disease

Clinical Trials in Cardiovascular Disease: A Companion to Braunwald's Heart Disease

by Charles H. Hennekens
     
 

Here's a companion to the well-respected and popular HEART DISEASE 5th Edition by Braunwald. Expertly edited, this text offers an assessment of treatments for cardiovascular disease, and provides evidence for and against accepted therapies. Coverage includes an introduction to cardiovascular disease, methodology, treatment trials, prevention trials and much more!

Overview

Here's a companion to the well-respected and popular HEART DISEASE 5th Edition by Braunwald. Expertly edited, this text offers an assessment of treatments for cardiovascular disease, and provides evidence for and against accepted therapies. Coverage includes an introduction to cardiovascular disease, methodology, treatment trials, prevention trials and much more! Features over 230 helpful illustrations.

Editorial Reviews

Doody's Review Service
Reviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
Description: This multiauthored text (58), intended to be a supplement to Braunwald's Heart Disease, 5th edition (W. B. Saunders, 1999), focuses on therapies for treatment and prevention of heart disease. It is divided into sections of methodology, treatments and prevention trials.
Purpose: The purpose is to provide information and knowledge in clinical trials in cardiology that are of value to patients.
Audience: The book is obviously intended for practitioners, but it is an excellent source for good reviews of many cardiovascular trials in recent years. Cardiology trainees as well as cardiologists would find it worthwhile.
Features: The first part of six chapters is devoted to the methodology of clinical trials, e.g. randomization, meta-analysis, population, data monitoring, etc. Various drug trials comprise the treatment section. There is a good review of the heparin and aspirin controversy which now may be out of date because of new information on low molecular weight heparin. The section on thrombolytic therapy is important, but now it is overshadowed by recent data on angioplasty in the treatment of acute myocardial infarctions if cath labs are available. The book is full of concise tables listing trials on the use of beta blockers, ace inhibitors, antiplatelet drugs for the treatment and management of myocardial infarctions. The chapters on the use of nitroglycerine and magnesium are interesting in that they fail to reduce mortality in acute myocardial infarctions. The importance of angioplasty in acute myocardial infarction and its use in combination with thrombolytic therapy and rescue angioplasty is discussed. The decision on whether to use angioplasty or thrombolytic therapy in the setting of an acute myocardial infarction now hinges on the availability of a cath lab and skilled personnel. There are trials of risk factors in the prevention section including smoking cessation, hypertension control, weight control, and exercise as well as the use of hormone replacement therapy, but written before the HERS trial. Each chapter is well referenced with these trials. There are many worthwhile tables complementing the text, especially the tables that list the clinical trials.
Assessment: This is a good source of material on drug trials that are well reviewed and listed in tables by diseases such as myocardial infarction, hypertension, and congestive heart failure. There is a particularly well detailed listing of the lipid trials and the effects of progression and regression of atherosclerosis lesions as well as a section on prevention. This book is valuable, but at this point suffers from the lack of the most recent data.
3 Stars from Doody
New England Journal of Medicine
This outstanding, thoroughly comprehensible and comprehensive, well-edited book succeeds admirably in its intention to serve as a resource on clinical trials in cardiovascular disease for those in research and in clinical practice. It provides an extensive, instructive review of statistical methods, a critical review of treatment trials, and a review of trials regarding prevention -- all of which explain and epitomize modern evidence-based medicine. This book is a worthy companion to Braunwald's Heart Disease, permitting readers to decide on their own the appropriateness of clinical guidelines and therapies, and is well worth the expense.
Booknews
An auxiliary to the fifth edition of Braunwals's textbook of cardiovascular medicine. Reviews current knowledge in cardiovascular disease medicine derived from clinical trials, and examines issues in clinical trial methods. Considers methodology from such perspectives as randomized trials, primary prevention versus high-rick versus secondary prevention trials, and meta-analysis. Describes treatment trials for aspirin and heparin, nitrates, lipid-lowering agents, congestive heart failure, and other agents and conditions. Among the prevention trials are those for reducing cholesterol, reducing stress, aspirin prophylaxis, antioxidant vitamins, and multiple-risk-factor intervention. A final chapter predicts future needs. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:
9780721668673
Publisher:
Elsevier Health Sciences
Publication date:
03/22/1999
Edition description:
Older Edition
Pages:
488
Product dimensions:
8.75(w) x 11.25(h) x (d)

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