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Clinical Trials in Cardiovascular Disease: A Companion to Braunwald's Heart Disease

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Here's a companion to the well-respected and popular HEART DISEASE 5th Edition by Braunwald. Expertly edited, this text offers an assessment of treatments for cardiovascular disease, and provides evidence for and against accepted therapies. Coverage includes an introduction to cardiovascular disease, methodology, treatment trials, prevention trials and much more! Features over 230 helpful illustrations.

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Philadelphia, PA 1999 Hard cover New. ABSOLLUTELY BRAND NEW (Gift Quality)! ! -No expedite, No international shipping available[GL3] Sewn binding. Cloth over boards. 488 p. ... Contains: Illustrations. Read more Show Less

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Overview

Here's a companion to the well-respected and popular HEART DISEASE 5th Edition by Braunwald. Expertly edited, this text offers an assessment of treatments for cardiovascular disease, and provides evidence for and against accepted therapies. Coverage includes an introduction to cardiovascular disease, methodology, treatment trials, prevention trials and much more! Features over 230 helpful illustrations.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
Description: This multiauthored text (58), intended to be a supplement to Braunwald's Heart Disease, 5th edition (W. B. Saunders, 1999), focuses on therapies for treatment and prevention of heart disease. It is divided into sections of methodology, treatments and prevention trials.
Purpose: The purpose is to provide information and knowledge in clinical trials in cardiology that are of value to patients.
Audience: The book is obviously intended for practitioners, but it is an excellent source for good reviews of many cardiovascular trials in recent years. Cardiology trainees as well as cardiologists would find it worthwhile.
Features: The first part of six chapters is devoted to the methodology of clinical trials, e.g. randomization, meta-analysis, population, data monitoring, etc. Various drug trials comprise the treatment section. There is a good review of the heparin and aspirin controversy which now may be out of date because of new information on low molecular weight heparin. The section on thrombolytic therapy is important, but now it is overshadowed by recent data on angioplasty in the treatment of acute myocardial infarctions if cath labs are available. The book is full of concise tables listing trials on the use of beta blockers, ace inhibitors, antiplatelet drugs for the treatment and management of myocardial infarctions. The chapters on the use of nitroglycerine and magnesium are interesting in that they fail to reduce mortality in acute myocardial infarctions. The importance of angioplasty in acute myocardial infarction and its use in combination with thrombolytic therapy and rescue angioplasty is discussed. The decision on whether to use angioplasty or thrombolytic therapy in the setting of an acute myocardial infarction now hinges on the availability of a cath lab and skilled personnel. There are trials of risk factors in the prevention section including smoking cessation, hypertension control, weight control, and exercise as well as the use of hormone replacement therapy, but written before the HERS trial. Each chapter is well referenced with these trials. There are many worthwhile tables complementing the text, especially the tables that list the clinical trials.
Assessment: This is a good source of material on drug trials that are well reviewed and listed in tables by diseases such as myocardial infarction, hypertension, and congestive heart failure. There is a particularly well detailed listing of the lipid trials and the effects of progression and regression of atherosclerosis lesions as well as a section on prevention. This book is valuable, but at this point suffers from the lack of the most recent data.
New England Journal of Medicine
This outstanding, thoroughly comprehensible and comprehensive, well-edited book succeeds admirably in its intention to serve as a resource on clinical trials in cardiovascular disease for those in research and in clinical practice. It provides an extensive, instructive review of statistical methods, a critical review of treatment trials, and a review of trials regarding prevention -- all of which explain and epitomize modern evidence-based medicine. This book is a worthy companion to Braunwald's Heart Disease, permitting readers to decide on their own the appropriateness of clinical guidelines and therapies, and is well worth the expense.
Booknews
An auxiliary to the fifth edition of Braunwals's textbook of cardiovascular medicine. Reviews current knowledge in cardiovascular disease medicine derived from clinical trials, and examines issues in clinical trial methods. Considers methodology from such perspectives as randomized trials, primary prevention versus high-rick versus secondary prevention trials, and meta-analysis. Describes treatment trials for aspirin and heparin, nitrates, lipid-lowering agents, congestive heart failure, and other agents and conditions. Among the prevention trials are those for reducing cholesterol, reducing stress, aspirin prophylaxis, antioxidant vitamins, and multiple-risk-factor intervention. A final chapter predicts future needs. Annotation c. Book News, Inc., Portland, OR booknews.com

3 Stars from Doody
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Product Details

  • ISBN-13: 9780721668673
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/22/1999
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 488

Table of Contents

Sect. I Methodology 1
1 Contributions of Basic Research, Observational Studies, and Randomized Trials 3
2 Methodology of Randomized Trials 9
3 Comparative Features of Primordial, Primary, and Secondary Prevention Trials 17
4 Large-Scale Randomized Trials 24
5 Principles of Data and Safety Monitoring Boards in Randomized Trials 31
6 Meta-Analysis of Randomized Trials 43
Sect. II Treatment Trials 53
7 Aspirin and Heparin 55
8 Thrombolytic Therapy 65
9 Beta Blockers 76
10 Angiotensin-Converting Enzyme Inhibitors 95
11 Calcium Channel Blockers 106
12 Magnesium 119
13 Nitrates 131
14 Direct Thrombin Inhibitors 145
15 Platelet Glycoprotein IIb/IIIa Receptor Inhibitors 166
16 Primary Angioplasty, Rescue Angioplasty, and New Devices 185
17 Lipid-Lowering Therapy 199
18 Antiarrhythmic Drug Therapy 217
19 Antiarrhythmic Drug Therapy in Supraventricular Tachycardia 231
20 Antithrombotic and Anticoagulant Therapy 245
21 Anticoagulant and Antiplatelet Drug Therapy in Atrial Fibrillation 257
22 Angioplasty and Bypass Surgery 267
23 Exercise 278
24 Congestive Heart Failure 296
25 Psychosocial Factors 315
Sect. III Prevention Trials 325
26 Cholesterol Reduction 327
27 Blood Pressure Reduction 341
28 Smoking Cessation 361
29 Exercise and Weight Loss 375
30 Aspirin 392
31 Postmenopausal Hormone Replacement Therapy 399
32 Antioxidant Vitamins 415
33 Dietary Factors 423
34 Multiple Risk Factor Intervention Trials 432
35 Prevention Strategies: From the Office to the Community 447
Index 461
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