Cognition and Cancer

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The majority of cancer patients on active treatment experience cognitive impairments often referred to as 'chemobrain' or 'chemofog'. In addition, patients with primary or metastatic tumors of the brain experience direct neurologic symptoms due, for example, to the location of their disease, surgical intervention, and the late effects of treatment such as radiotherapy. The aim of this book is to serve as a resource for health care professionals working with cancer patients who experience cognitive changes as a result of their cancer and its treatment. It provides practical information to help improve care by reviewing and describing brain-behavior relationships; research-based evidence on cognitive changes that occur with various cancers and cancer treatments; assessment techniques, including neurocognitive assessment and neuroimaging techniques; and intervention strategies for affected patients. In short, it will explain how to identify, assess and treat these conditions.

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Editorial Reviews

Doody's Review Service
Reviewer: Christopher J Graver, PhD, ABPP-CN(Madigan Healthcare System)
Description: As cancer treatments improve and mortality is decreased, clinicians find themselves faced with the aftermath of not only the cancer, but also its treatments. Understanding the neuropsychological effects of cancer and cancer treatments is an important step in the healing process and critical for improving quality of life post-treatment. This book brings together the relevant literature on the relationship between cognition and cancer.
Purpose: The aim is to pioneer a book that gathers recent research into cognition and cancer in a single source.
Audience: Clinicians from a variety of fields will find this of interest. Neuropsychologists are certainly at the top of the list, but other providers, such as neurologists and oncologists, will also find this of interest. Therapists involved in rehabilitation could benefit from this book as well. The editor and contributing authors include a number of experts in the field, as well as board certified neuropsychologists.
Features: The book begins with a general introduction to neuropsychology, which includes a brief history of the field, the types of domains assessed by neuropsychologists, and some reasons for referral with cancer patients. This is followed by a review of neuroimaging findings in cancer patients with a color plate at the end of the chapter. The next few chapters explore neuropsychological assessment, including suggested tests and batteries for adults and children. This is done at a general level, with later chapters addressing more specific types of cancer and treatments. Types of cancers range from leukemia to gliomas to paraneoplastic syndromes while treatments cover radiation to chemotherapy to hormone replacement. Late effects are discussed, which is an important issue for school-aged children. The final chapters are geared more towards support and rehabilitation, but the final chapter tackles the topic of clinical trials. The organization of the chapters is well done and includes helpful figures, such as MRI slides of tumors to help visualize neuroanatomical localization. Summaries end each chapter and the references are very current.
Assessment: Although the neuropsychology of cancer is in its infancy, this book is an indispensable part of a well rounded library on the topic. Readers will find information about assessment batteries, neuropsychological findings, and rehabilitation for the variety of cancer types and treatments they are most likely to encounter.
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Product Details

  • ISBN-13: 9780521854825
  • Publisher: Cambridge University Press
  • Publication date: 12/31/2008
  • Pages: 353
  • Product dimensions: 7.30 (w) x 9.80 (h) x 0.90 (d)

Meet the Author

Christina A. Meyers is Professor and Chief of the Section of Neuropsychology, Department of Neuro-Oncology at The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

James R. Perry holds the Tony Crolla Chair in Brain Tumour Research and is Head of the Division of Neurology at the Sunnybrook Health Sciences Centre and Odette Cancer Centre, University of Toronto, Canada.

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Table of Contents

List of contributors vii

Preface xi

Section 1 Cognition and the brain: measurement, tools, and interpretation

1 Introduction Christina A. Meyers James R. Perry 3

2 Clinical neuropsychology Jill B. Rich Angela K. Troyer 6

3 Brain imaging investigation of chemotherapy-induced neurocognitive changes Brenna C. McDonald Andrew J. Saykin Tim A. Ahles 19

4 Role of Neuropsychological assessment in cancer patients Elana Farace 33

5 Neuropsychological assessment of adults with cancer Anne E. Kayl Robert Collins Jeffrey S. Wefel 44

6 Neuropsychological assessment of children with cancer Louise Penkman Fennell Robert W. Butler 56

Section 2 Effects of cancer and cancer treatment on cognition

7 Biological bases of radiation injury to the brain Edward G. Shaw Mike E. Robbins 83

8 Cognitive dysfunction related to chemotherapy and biological response modifiers Jeffrey S. Wefel Robert Collins Anne E. Kayl 97

9 Effect of hormones and hormonal treatment on cognition Christien Schilder Sanne Schagen Frits van Dam 115

10 Low-grade Gliomas Martin J. B. Taphoorn Charles G. Ni&eumlet;l 142

11 High-grade Gliomas Michael J. Glantz John W. Conlee 156

12 Brain metastases Deepak Khuntia Beela S. Mathew Christina A. Meyers Sterling Johnson Minesh P. Mehta 170

13 Primary central nervous system lymphoma Denise D. Correa 187

14 Childhood brain tumors H. Stacy Nicholson Louise Penkman Fennell Robert W. Butler 198

15 Neurofibromatosis Bartlett D. Moore, Ill John M. Slopis 211

16 Hematological malignancies Melissa Friedman Mercedes Fernandez 228

17 Paraneoplastic disorders Edward Dropcho 239

18 Symptomatic therapies and supportive care issues Alan Valentine Eduardo Bruera258

19 Animal models and cancer-related symptoms Adrian Dunn 270

Section 3 Interventions and implications for clinical trials

20 Behavioral strategies and rehabilitation Dona E. C. Locke Jane H. Cerhan James F. Malec 281

21 Support services Bebe Guill Renee H. Raynor 295

22 Pharmacological Interventions for the treatment of radiation-induced brain injury Edward G. Shaw Jerome Butler L. Douglas Case Ralph d'Agostino, Jr. John Gleason, Jr. Edward Ip Mike E. Robbins Paul Saconn Stephen R. Rapp 312

23 Neurocognitive testing in clinical trials Jennifer A. Smith Jeffrey S. Wefel 320

Index 329

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