Cognition and Cancer


Most people afflicted by cancer will experience cognitive impairment, sometimes referred to as 'chemobrain' or' chemofog', due to the various direct and indirect effects of their disease and its treatment. In addition, patients with primary or metastatic tumors of the brain experience direct neurologic symptoms due, for example, to the location of their disease, surgical intervention, and the late effects of treatment such as radiotherapy. The aim of this book is to serve as a resource for health care ...

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Most people afflicted by cancer will experience cognitive impairment, sometimes referred to as 'chemobrain' or' chemofog', due to the various direct and indirect effects of their disease and its treatment. In addition, patients with primary or metastatic tumors of the brain experience direct neurologic symptoms due, for example, to the location of their disease, surgical intervention, and the late effects of treatment such as radiotherapy. The aim of this book is to serve as a resource for health care professionals working with cancer patients who experience cognitive changes as a result of their cancer and its treatment. It provides practical information to help improve care by reviewing and describing brain-behavior relationships; research-based evidence on cognitive changes that occur with various cancers and cancer treatments; assessment techniques, including neurocognitive assessment and neuroimaging techniques; the future of neurocognitive research in the area, including animal models and clinical trials; and intervention strategies for affected patients. In short, it will explain how to identify, assess, and treat these conditions.

This book is essential reading for anyone involved in the clinical care of cancer patients with neurocognitive problems, or who undertake research in this area.

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Editorial Reviews

Doody's Review Service
Reviewer: Christopher J Graver, PhD, ABPP-CN(Madigan Healthcare System)
Description: As cancer treatments improve and mortality is decreased, clinicians find themselves faced with the aftermath of not only the cancer, but also its treatments. Understanding the neuropsychological effects of cancer and cancer treatments is an important step in the healing process and critical for improving quality of life post-treatment. This book brings together the relevant literature on the relationship between cognition and cancer.
Purpose: The aim is to pioneer a book that gathers recent research into cognition and cancer in a single source.
Audience: Clinicians from a variety of fields will find this of interest. Neuropsychologists are certainly at the top of the list, but other providers, such as neurologists and oncologists, will also find this of interest. Therapists involved in rehabilitation could benefit from this book as well. The editor and contributing authors include a number of experts in the field, as well as board certified neuropsychologists.
Features: The book begins with a general introduction to neuropsychology, which includes a brief history of the field, the types of domains assessed by neuropsychologists, and some reasons for referral with cancer patients. This is followed by a review of neuroimaging findings in cancer patients with a color plate at the end of the chapter. The next few chapters explore neuropsychological assessment, including suggested tests and batteries for adults and children. This is done at a general level, with later chapters addressing more specific types of cancer and treatments. Types of cancers range from leukemia to gliomas to paraneoplastic syndromes while treatments cover radiation to chemotherapy to hormone replacement. Late effects are discussed, which is an important issue for school-aged children. The final chapters are geared more towards support and rehabilitation, but the final chapter tackles the topic of clinical trials. The organization of the chapters is well done and includes helpful figures, such as MRI slides of tumors to help visualize neuroanatomical localization. Summaries end each chapter and the references are very current.
Assessment: Although the neuropsychology of cancer is in its infancy, this book is an indispensable part of a well rounded library on the topic. Readers will find information about assessment batteries, neuropsychological findings, and rehabilitation for the variety of cancer types and treatments they are most likely to encounter.
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Product Details

  • ISBN-13: 9781107411814
  • Publisher: Cambridge University Press
  • Publication date: 12/13/2012
  • Pages: 356
  • Product dimensions: 7.40 (w) x 9.60 (h) x 0.90 (d)

Meet the Author

Christina A. Meyers is Professor and Chief of the Section of Neuropsychology, Department of Neuro-Oncology at The University of Texas M.D. Anderson Cancer Center, Houston, Texas.

James R. Perry holds the Tony Crolla Chair in Brain Tumour Research and is Head of the Division of Neurology at the Sunnybrook Health Sciences Centre and Odette Cancer Centre, University of Toronto, Canada.

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Table of Contents

Preface; List of contributors; Part I. Cognition and the Brain: Measurement, Tools, and Interpretation: 1. Introduction Christina A. Meyers and James R. Perry; 2. Clinical neuropsychology Jill B. Rich and Angela K. Troyer; 3. Brain imaging investigation of chemotherapy-induced neurocognitive changes Brenna C. McDonald, Andrew J. Saykin and Tim A. Ahles; 4. Role of neuropsychological assessment in cancer patients Elana Farace; 5. Neuropsychological assessment of adults with cancer Anne E. Kayl, Robert Collins, and Jeffrey S. Wefel; 6. Neuropsychological assessment of children with cancer Louise Penkman Fennell and Robert W. Butler; Part II. Effects of Cancer and Cancer Treatment on Cognition: 7. Biological bases of radiation injury to the brain Edward G. Shaw and Mike E. Robbins; 8. Chemotherapy and biological response modifier-related cognitive dysfunction Jeffrey S. Wefel, Robert Collins and Anne E. Kayl; 9. Effect of hormones and hormonal treatment on cognition Christien Schilder, Sanne Schagen and Frits van Dam; 10. Low grade gliomas Martin J. B. Taphoorn and Charles G. Niel; 11. High grade gliomas Michael J. Glantz and James R. Perry; 12. Brain metastases Deepak Khuntia, Beela S. Mathew, Christina A. Meyers, Sterling Johnson and Minesh P. Mehta; 13. Primary Central Nervous System lymphoma Denise D. Correa; 14. Childhood brain tumors H. Stacy Nicholson, Louise Penkman Fennell and Robert W. Butler; 15. Neurofibromatosis Bartlett D. Moore, III and John M. Slopis; 16. Hematological malignancies Melissa Friedman and Mercedes Fernandez; 17. Paraneoplastic disorders Edward Dropcho; 18. Symptomatic therapies and supportive care issues Alan Valentine and Eduardo Bruera; 19. Animal models and cancer related symptoms Adrian Dunn; Part III. Interventions and Implications for Clinical Trials: 20. Behavioral strategies and rehabilitation Dona E. C. Locke, Jane H. Cerhan and James F. Malec; 21. Support services Bebe Guill and Renee H. Raynor; 22. Pharmacologic interventions for the treatment of radiation-induced brain injury Edward G. Shaw, Jerome Butler, L. Douglas Case, Ralph d'Agostino, Jr., John Gleason, Jr., Edward Ip, Mike E. Robbins, Paul Saconn and Stephen R. Rapp; 23. Neurocognitive testing in clinical trials Jennifer A. Smith and Jeffrey S. Wefel.
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