Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms / Edition 1

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Overview

This volume covers recent research on all aspects of colon cancer prevention, including normal and abnormal colonic development, chemoprevention of colon cancer, the role of dietary factors in prevention, experimental approaches and mechanisms in prevention, as well as whether cell proliferation and apoptosis is the link between relative risk and prevention. Topics include: transcriptional regulation in intestinal development; colonic cell proliferation, differentiation and apoptosis; defects in the regulation of beta-catenin in colorectal cancer; dietary lipids, inflammation, and colon cancer; sulindac sulfone-induced regression of rectal polyps in patients with familial adenomatous polyposis; prevention of colon cancer and modulation of aberrant crypt foci; cell proliferation and apoptosis by retinoids and NSAIDs; mechanisms by which energy restriction inhibits carcinogenesis; dietary intervention studies of colorectal cancer; the genetics of hereditary non-polyposis colorectal cancer and non-polypotic colon cancer; familial association; colonic cell proliferation and apoptosis in rodent species; and nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase and the cell cycle and their interactions in cancer.

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Product Details

Table of Contents

Preface. 1. Transcriptional Regulation in Intestinal Development: Implications for Colorectal Cancer; P.G. Traber. 2. Colonic Cell Proliferation, Differentiation and Apoptosis; L. Augenlicht, et al. 3. Defects in the Regulation of beta-Catenin in Colorectal Cancer; P. Polakis, et al. 4. Dietary Lipids, Inflammation and Colon Cancer; C.N. Kuratko. 5. Sulindac Sulfone Induced Regression of Rectal Polyps in Patients with Familial Adenomatous Polyposis; G.D. Stoner, et al. 6. Prevention of Colon Cancer and Modulation of Aberrant Crypt Foci, Cell Proliferation and Apoptosis by Retinoids and NSAIDS; M.A. Pereira. 7. Digested Fiber From Wheat Bran Induces CDK Inhibitors Which Block Colon Epithelial Cells in Gl; E.A. Friedman, J. Wang. 8. Mechanisms by Which Energy Restriction Inhibits Carcinogenesis; H.J. Thompson, et al. 9. Dietary Intervention Studies of Colorectal Cancer; A. Schatzkin. 10. The Genetics of Hereditary Non-polyposis Colorectal Cancer and Non-polypotic Colon Cancer; P. Peltomaki. 11. Familial Association; R.W. Burt. 12. Colonic Cell Proliferation and Apoptosis in Rodent Species: Modulation by Diet; R.S. Chapkin, J.R. Lupton. 13. Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Cyclooxygenase and the Cell Cycle: Their Interactions in Colon Cancer; B. Rigas, S.J. Shiff. Poster Abstracts. Index.

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