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Combination Therapy of AIDS / Edition 1

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Overview

Combination antiretroviral therapy of AIDS is a subject that has recently become a discipline of its own. For the first time, all facets are considered in a single volume. Combination drug treatment of AIDS is examined from different perspectives, including the history and basis, economic and theoretical considerations. Virological, immunological, clinical and practical reasons for therapy failures are given as well as strategies for preventing or overcoming therapy failures. This work makes an important contribution to the current literature on clinical therapeutics. It is of interest for clinicians, researchers, public health workers, specialists and non-specialists seeking to optimize the treatment of AIDS.
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Editorial Reviews

Doody's Review Service
Reviewer: Joan Cannon, PharmD (Edward Hines Jr. VA Hospital)
Description: This book, one in the Milestones in Drug Therapy series, is a compilation of the most relevant topics surrounding combination antiretroviral therapy, such as the efficacy of single versus dual versus triple-class HAART, management of HAART failure, and the debate regarding structured therapy interruptions.
Purpose: This book successfully details the complexity of combination antiretroviral therapy. Beginning with the history and evolution of antiretroviral therapy, this book leads into the many aspects of therapeutic considerations to provide direction regarding the most advantageous use of antiretroviral therapy.
Audience: The book is written for clinicians, healthcare workers, basic and clinical researchers, and drug designers who are involved with some aspect of the HIV/AIDS specialty. This book would be a difficult read for those who do not possess a baseline knowledge of HIV/AIDS and antiretroviral therapy. The editors, as well as the majority of the authors of the chapters, appear to be experts in their field as demonstrated by significant contributions to the HIV/AIDS literature outside of this book.
Features: The contributors appear to use the most up-to-date and relevant references which allows the reader to glean the necessary information without being bogged down with excessive details. Furthermore, complex or detailed concepts are presented in figures or tables or other resources are referred to when necessary. For example, the drug interactions section in the chapter on pharmacokinetics and pharmacodynamics refers the reader to a useful Web site dealing with drug interactions of antiretrovirals.
Assessment: This is a valuable and unique addition to the HIV/AIDS literature as it focuses solely on issues surrounding antiretroviral therapy. However, as with any book dealing with HIV/AIDS, it runs the risk of being outdated quickly, thereby requiring frequently updated versions.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9783764366001
  • Publisher: Birkhauser Basel
  • Publication date: 10/30/2007
  • Series: Milestones in Drug Therapy Series
  • Edition description: 2004
  • Edition number: 1
  • Pages: 243
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.63 (d)

Table of Contents

List of contributors
Preface
Anti-HIV agents to be used in drug combination regimens 1
A perspective of the history of HAART 25
The basic principles for combination therapy 41
Comparison of the efficacy of HAART : single, dual or triple-class antiretroviral therapy 53
Pharmacokinetics and pharmacodynamics of HAART 73
Primary HIV infection : from diagnosis to treatment 87
Salvage therapy 99
Structured therapy interruptions (STIs) : lessons from a therapeutic strategy 115
Immune reconstitution in HIV infection 127
Highly active antiretroviral treatment (HAART) of pediatric HIV-1 infection 141
Causes of HIV treatment failure 159
Economic implication of HIV-I resistance testing in overall clinical care 195
Guidelines for antiretroviral therapy 205
Visions for the future of antiretroviral therapy 225
Index 239
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