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Doody's Review ServiceReviewer: Joan Cannon, PharmD (Edward Hines Jr. VA Hospital)
Description: This book, one in the Milestones in Drug Therapy series, is a compilation of the most relevant topics surrounding combination antiretroviral therapy, such as the efficacy of single versus dual versus triple-class HAART, management of HAART failure, and the debate regarding structured therapy interruptions.
Purpose: This book successfully details the complexity of combination antiretroviral therapy. Beginning with the history and evolution of antiretroviral therapy, this book leads into the many aspects of therapeutic considerations to provide direction regarding the most advantageous use of antiretroviral therapy.
Audience: The book is written for clinicians, healthcare workers, basic and clinical researchers, and drug designers who are involved with some aspect of the HIV/AIDS specialty. This book would be a difficult read for those who do not possess a baseline knowledge of HIV/AIDS and antiretroviral therapy. The editors, as well as the majority of the authors of the chapters, appear to be experts in their field as demonstrated by significant contributions to the HIV/AIDS literature outside of this book.
Features: The contributors appear to use the most up-to-date and relevant references which allows the reader to glean the necessary information without being bogged down with excessive details. Furthermore, complex or detailed concepts are presented in figures or tables or other resources are referred to when necessary. For example, the drug interactions section in the chapter on pharmacokinetics and pharmacodynamics refers the reader to a useful Web site dealing with drug interactions of antiretrovirals.
Assessment: This is a valuable and unique addition to the HIV/AIDS literature as it focuses solely on issues surrounding antiretroviral therapy. However, as with any book dealing with HIV/AIDS, it runs the risk of being outdated quickly, thereby requiring frequently updated versions.