Comparative Biology of Aging / Edition 1

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More About This Textbook


Aging and death remain one of the most fascinating, and mysterious, areas of biological research. Huge anomalies between species raise questions the answers to which could have fundamental implications for the field of medical science. As scientists unlock the secrets of the exceptionally long-lived little brown bat (up to 34 years), or the common Budgerigar which despite having a metabolic rate 1.5 times that of a laboratory mouse, can live for up to 20 years, it has become more important than ever to be able to make a comparative analysis of the various species used in research.

Dealing with every one of the species that are employed in laboratory research, this is the first book on the subject of aging that provides detailed comparative data for age-related changes in its subjects. It does so at the level of the whole animal, its organs, organelles and molecules. The comparative data, supplied in 15 chapters by leading experts, provides information on fields as disparate as telomere function and loss, the importance of the Sirtuins and Tor, the influence of hormones on lifespans, the relationship between body size and lifespan, the effects of restricted calorific intake, age-related changes in cell replication, and DNA damage and repair. Chapters are devoted to cardiac aging, comparative skeletal muscle aging, the aging of the nervous and immune systems, the comparative biology of lyosomal function and how it is affected by age, and many other key areas of research.

This much-needed text will provide scientists working in a wide spectrum of fields with key data to aid them in their studies.

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Product Details

  • ISBN-13: 9789048134649
  • Publisher: Springer Netherlands
  • Publication date: 1/1/2010
  • Edition description: 2010
  • Edition number: 1
  • Pages: 391
  • Product dimensions: 6.10 (w) x 9.20 (h) x 1.10 (d)

Table of Contents

Introduction: Lifespans and Pathologies Present at Death in Laboratory Animals Norman S. Wolf Steven Austad 1

Animal Size, Metabolic Rate, and Survival, Among and Within Species Steven N. Austad 27

Hormonal Influences on Aging and Lifespan Adam Spong Andrzej Bartke 43

Exploring Mechanisms of Aging Retardation by Caloric Restriction: Studies in Model Organisms and Mammals Rozalyn M. Anderson Ricki J. Colman Richard Weindruch 69

Cell Replication Rates In Vivo and In Vitro and Wound Healing as Affected by Animal Age, Diet, and Species Norman S. Wolf 97

Sirtuin Function in Longevity Daniel L. Smith Jr. Jeffrey S. Smith 123

The Role of TOR Signaling in Aging Matt Kaeberlein Lara S. Shamieh 147

Mitochondria, Oxidative Damage and Longevity: What Can Comparative Biology Teach Us? Yun Shi, Rochelle Buffenstein Holly Van Remmen 163

Comparative Genomics of Aging Jan Vijg, Ana Maria Garcia, Brent Calder, and Martijn Dollé 191

Changes in Lysosomes and Their Autophagic Function in Aging: The Comparative Biology of Lysosomal Function Samantha J. Orenstein Ana Maria Cuervo 201

Telomeres and Telomerase N.M.V. Gomes J.W. Shay W.E. Wright 227

Cardiac Aging Dao-Fu Dai Robert J. Wessells Rolf Bodmer Peter S. Rabinovitch 259

Comparative Skeletal Muscle Aging David J. Marcinek Jonathan Wanagat Jason J. Villarin 287

Aging of the Nervous System Catherine A. Wolkow Sige Zou Mark P. Mattson 319

Aging of the Immune System Across Different Species Janko Nikolich-Žugich Luka Čičin-Šain 353

Index 377

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