Comprehensive Chiroptical Spectroscopy, Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules

Overview

This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to ...
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Comprehensive Chiroptical Spectroscopy, Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules

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Overview

This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.
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Product Details

  • ISBN-13: 9781118012925
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 4/3/2012
  • Edition number: 1
  • Pages: 872
  • Product dimensions: 7.10 (w) x 10.10 (h) x 1.90 (d)

Meet the Author

Nina Berova is a Research Professor in the Department of Chemistry at Columbia University. She has been a coeditor of the journal Chirality (Wiley) since 1998.

Prasad L. Polavarapu is currently a Professor of Chemistry at Vanderbilt University.

Koji Nakanishi is one of the world's leading natural products chemists and was editor of the journal, The Chemical Record (Wiley). He retired from Columbia University in 2007, but continues to conduct research.

Robert W. Woody is an Emeritus Professor at Colorado State University.

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Table of Contents

Comprehensive Chiroptical Spectroscopy Vol. 2 (N. Berovam P. L. Polavarapu, K. Nakanishi, R. W. Woody).

2. The First Decades after the Discovery of Circular Dichroism and Optical Rotatory Dispension by Aimé Cotton in 1895: An Historical Overview (Peter Laur).

2.1 Some Inherently Chiral Chromophores – Empirical Rules and Quantum Chemical Calculation (Jacek Gawronski, Marcin Kwit, Pawel Skowronek, Jadwiga Frelek, Aleksandra Butkiewicz and Magdalena Woznica).

2.2 Electronic CD of Benzene and Other Aromatic Chromophores for Determination of Absolute Configuration (Tibor Kurtan, Sandor Antus and Gennaro Pescitelli).

2.3 Electronic CD Exciton Chirality Method: Principles and Applications (Nina Berova, Koji Nakanishi and Nobuyuki Harada).

2.4 CD Spectra of Chiral Extended π-Electron Compounds: Theoretical Determination of the Absolute Stereochemistry and Experimental Verification (Nobuyuka Harada and Shunsuke Kuwahara).

2.5 Assignment of the Absolute Configurations of Natural Products by Means of Solid-State Electronoic Circular Dichroism and Quantum-Mechanical Calculations (Gennaro Pescitelli and Tibor Kurtan).

2.6 Dynamic Stereochemistry and Chiroptical Spectroscopy of Metallo-organic Compounds (James Canary and Zhaohua Dai).

2.7 Circular Dichroism in Dynamic Systems: Switching Molecular and Supramolecular Chirality (Ben Feringa, Angela Mammana and Gregory T. Carroll).

2.8 Electronic Circular Dichroism of Supramolecular Systems (Yoshi Inoue and Cheng Yang).

2.9 The Online Stereochemical Analysis of Chiral Compounds by HPLC-ECD Coupling in Combination with Quantum-Chemical Calculations (Gerhard Bringmann, Daniel Götz and Torsten Bruhn).

2.10 Determination of the Structures of Chiral Natural Products Using Vibrational Circular Dichroism (Prasad L. Polavarapu).

2.11 Determination of Molecular Absolute Configuration: Guidelines for Selecting a Suitable Chiroptical Approach (Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo and Egidio Giorgio).

2.12 Applications of Electronic Circular Dichroism to Inorganic Stereochemistry (Sumio Kaizaki).

2.1 The Electronic Circular Dichroism of Proteins (Robert W. Woody).

2.2 Electronic Circular Dichroism of Peptides (Claudio Toniolo, Fernando Formaggio and Robert W. Woody).

2.3 Electronic Circular Dichroism of Peptodomimetrics (Claudio Toniolo and Fernando Formaggio).

2.4 Circular Dichroism Spectroscopy of Nucleic Acids (Jaroslav Kypr, Iva Kejnovska, Michaela Vorlickova and Klára Bednářová).

2.5 Electronic Circular Dichroism of Peptide Nucleic Acids and Their Analogs (Roberto Corradini, Tullia Tedeschi, Stefano Sforza and Rosangela Marchelli).

2.6 Circular Dichroism of Protein-Nucleic Avid Interactions (Donald M. Gray).

2.7 Drug and Natural Product Binding to Nucleic Acids Analyzed by Electronic Circular Dichroism (George Ellestad).

2.8 Probing HAS and AGP Drug Binding Sites by Electronic Circular Dichroism (Miklos Simonyi).

2.9 Conformational Studies of Biopolymers, Peptides, Proteins and Nucleic Acids. A Role for Vibrational Circular Dichroism (Tim Keiderling and Ahmed Lakhani).

2.10 Structure and Behavior of Biomolecules from Raman Optical Activity (Laurence D. Barron and Lutz Hecht).

2.11 Optical Rotation Electronic Circular Dichroism and Vibrational Circular Dichroism of Carbohydrates and Glycoconjugates (Kenji Monde and Tohru Taniguchi).

2.12 Electronic Circular Dichroism in Drug Discovery (Carlo Bertucci and Marco Pistolozzi).

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