Comprehensive Dermatologic Drug Therapy: Expert Consult - Online and Print


Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for.

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Comprehensive Dermatologic Drug Therapy: Expert Consult - Online

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Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for.

• Prescribe with confidence
thanks to quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols.
Assess your knowledge and prepare for certification or recertification with more than 800 review questions and answers throughout the book.
Contain costs and meet patient expectations with purchase information provided for major drugs.
Quickly evaluate drug options for each disease discussed using a highly detailed, disease-specific index.

• Discover the best uses for new biologic therapeutics
such as ustekinumab and rituximab, as well as newly improved TNF inhibitors.
Offer your patients the very latest in cosmetic procedures, including chemical peels, intradermal fillers, and botulinum toxin.
Use the safest and most effective drugs possible with new chapters on irritants and allergens in topical therapeutic agents, plus a new, separate chapter on mycophenolate mofetil.
Review drugs recently taken off the market by the FDA, and use that knowledge to improve your current dermatologic drug therapy.
Access the complete contents online at and perform rapid searches for drug indications, interactions, monitoring guidelines, and much more.

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Editorial Reviews

Doody's Review Service
Reviewer: Patricia Wong, MD (Stanford University Medical Center)
Description: This is an amazing reference on dermatologic drugs. It goes well beyond discussing side-effects, dosages, laboratory monitoring, and disease indications. It is loaded with practical tips on what to expect when beginning treatment with a particular drug, potential pitfalls, and which patients may be at higher risk for adverse reactions. Useful tables outline the differences in topical medications that could be prescribed for the same condition. For example, which topicals are manufactured with propylene glycol? This could make a difference in what you choose to treat, for example, a tinea infection. This third edition is bigger and better than its two predecessors published in 2007 and 2001.
Purpose: It is intended to be the comprehensive resource for dermatologic drugs, topical prescription and nonprescription agents (many of which are over-the-counter products such as insect repellants, shampoos), and cosmetic products.
Audience: The audience is dermatologists, dermatology residents, and primary care internists who want to be knowledgeable about treating skin conditions.
Features: All the information is incredibly current. The chapters are organized by similar mechanisms of action: antibacterial, cytotoxic, phototherapy, TNF inhibitors, IVIG, etc. Each chapter starts out with important questions that highlight the main concepts. As a topic is discussed, the number of the question is highlighted at the beginning of the paragraph. There are important discussions of drug syndromes and current recommendations for treatment. Clear monitoring guidelines are outlined. Nice, spacious tables diagram mechanism of action of various drugs. Drugs that are used in Europe but not the U.S. are covered, which is helpful when seeing a patient who is from another country, or a U.S. patient who happened to be treated by a physician outside the U.S. Basic principles of drug treatment are presented. Drugs that were removed from the market after being approved are discussed. The practical information on which drugs can be most helpful for treating a particular disease, and the nuances in dosing and avoiding/minimizing certain complications are invaluable. The book comes with a code to access an online version.
Assessment: Clinicians will love this book. You cannot legitimately consider yourself a real dermatologist if you do not have this reference in your armamentarium. I recommend that all dermatologists buy two copies — one for the office and one for home. This is a superb book and I am delighted to own it!
From the Publisher
"Clinicians will love this book. You cannot legitimately consider yourself a real dermatologist if you do not have this reference in your armamentarium. I recommend that all dermatologists buy two copies — one for the office and one for home. This is a superb book and I am delighted to own it!"- Patricia Wong, MD (Stanford University Medical Center) 5 star Doody Rating!
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Product Details

  • ISBN-13: 9781437720037
  • Publisher: Elsevier Health Sciences
  • Publication date: 11/30/2012
  • Edition number: 3
  • Pages: 1024
  • Sales rank: 393,642
  • Product dimensions: 8.58 (w) x 10.70 (h) x 1.26 (d)

Table of Contents

List of contributors ix

Preface xv

Dedication xvii

Acknowledgements xix

A dozen suggestions to help the reader optimally utilize this book xxi

Part I Introduction

1 Basic principles of pharmacology Stephen E. Wolverton 1

2 Principles for maximizing the safety of dermatologic drug therapy Stephen E. Wolverton 12

3 Polymorphisms: why individual drug responses vary Cynthia M. C. DeKlotz Stephen E. Wolverton Benjamin N. Lockshin 21

4 Adherence to drug therapy Michelle M. Levender Steven R. Feldman 34

Part II Important Drug Regulatory Issues

5 The FDA drug approval process William H. Eaglstein 41

6 Pharmacovigilance: verifying that drugs remain safe Joel M. Gelfand Sinéad M. Langan 46

7 Drugs taken off the market: important lessons learned Stephen E. Wolverton Susan J. Walker 54

Part III Systemic Drugs for Infectious Diseases

8 Systemic antibacterial agents Susun Kim Brent D. Michaels Grace K. Kim James Q. Del Rosso 61

9 Systemic antifungal agents Aditya K. Gupta 98

10 Systemic antiviral agents George D. Magel Kassie A. Haitz Whitney J. Lapolla Catherine M. DiGiorgio Natalia Mendoza Stephen K. Tyring 121

11 Systemic antiparasitic agents Dirk Elston 135

Part IV Systemic Immunomodulatory and Antiproliferative Drugs

12 Systemic corticosteroids Stephen E. Wolverton 143

13 Methotrexate Jeffrey P. Callen Carol L. Kulp-Shorten 169

14 Azathioprine Stephanie S. Badalamenti Francisco A. Kerdel 182

15 Mycophenolate mofetil and mycophenolic acid Courtney R. Schadt Jeffrey P. Zwerner 190

16 Cyclosporine Tina Bhutani Chai Sue Lee John Y. M. Koo 199

17 Cytotoxic agents Whitney A. High 212

18 Dapsone Kim Edhegard Russell P. Hall III 228

19 Antimalarial agents Jeffrey P. Callen Charles Camisa 241

20 Systemic retinoids Timothy J. Patton Laura K. Ferris 252

21 Interferons Brian Berman Caroline V. Caperton 269

Part V Drugs Used in Conjunction with Ultraviolet or Visible Light

22 PUVA photochemotherapy and other phototherapy modalities Warwick L. Morison Elisabeth G. Richard 279

23 Extracorporeal photochemotherapy (photopheresis) Jaehyuk Choi Peter W. Heald Michael Girardi 291

24 Photodynamic therapy Jaggi Rao Robert Bissonnette 299

Part VI Biological Therapeutics

25 Tumor necrosis factor (TNF) inhibitors Stephanie Mehlis Kenneth B. Gordon 307

26 Interleukin 12/23 inhibitors Jason J. Emer Amir Larran Mark G. Lebwohl 319

27 Rituximab and future biological therapies Craig L. Leonardi Michael P. Heffernan Jennifer G. Gill 333

VII Miscellaneous Systemic Drugs

28 Antihistamines Malcolm W. Greaves 343

29 Vasoactive and antiplatelet agents Seth B. Forman Katherine Roy Algin B. Garrett 353

30 Antiandrogens and androgen inhibitors Marty E. Sawaya Najwa Somani 361

31 Psychotropic agents Tina Bhutani Chai Sue Lee John Y. M. Koo 375

32 Intravenous immunoglobulin therapy Tobias Goerge Thomas A. Luger 389

33 Systemic anticancer agents: dermatologic indications and adverse events Alyx C. Rosen Cristina Gómez-Fernández Lawrence A. Mark John A. Zic Mario E. Lacouture 397

34 Drugs for the skinternist Megan N. Landis David R. Adams 408

35 Miscellaneous systemic drugs Loretta S. Davis Keith G. LeBlanc Jr. Alfred L. Knable Jr. Cindy E. Owen 424

Part VIII Topical Drugs for Infectious Diseases

36 Topical antibacterial agents Kiran Motaparthi Sylvia Hsu 445

37 Topical antifungal agents Rhea M. Phillips Theodore Rosen 460

38 Topical and intralesional antiviral agents Pranav B. Sheth Megan N. Landis 473

39 Topical antiparasitic agents Shiva S. Krishnan Benjamin N. Lockshin 481

Part IX Topical Immunomodulatory and Antiproliferative Drugs

40 Topical corticosteroids Michael R. Warner Charles Camisa 487

41 Topical retinoids Naveed Sami 505

42 Topical and intralesional chemotherapeutic agents Anjali V. Morales Eunice Y. Tsai Youn H. Kim 518

43 Topical contact allergens Andrew N. Lin 527

44 Topical calcineurin inhibitors Andrew N. Lin 535

45 Topical Vitamin D3 Ginette A. Hinds Yolanda R. Helfrich Dana L. Sachs Sewon Kang 543

Part X Miscellaneous Topical Drugs

46 Sunscreens Stanley B. Levy 551

47 Therapeutic shampoos Blair K. Young Robert T. Brodell Kevin D. Cooper 562

48 α-Hydroxy acids Amy B. Lewis Samantha M. Lee 570

49 Chemical peels Melanie Kingsley Andrei I. Metelitsa Ally-Khan Somani 579

50 Products for the care of chronic wounds Swetha Kandula Sarika M. Ramachandran Richard A. Clark 584

51 Agents used for treatment of hyperkeratosis Adam B. Hessel Julio C. Cruz-Ramon Dana M. Klinger Andrew N. Lin 595

52 Cosmetic therapy Zoe D. Draelos 604

53 Irritants and allergens: when to suspect topical therapeutic agents Michael Sheehan Nico Mousdicas Matthew J. Zirwas 613

54 Insect repellents Mark S. Fradin 620

55 Miscellaneous topical agents Katherine Roy Seth B. Forman 629

Part XI Injectable and Mucosal Routes of Drug Administration

56 Local anesthetics Michael J. Huether Christine H. Weinberger David G. Brodland 637

57 Injectable dermal and subcutaneous fillers Melanie Kingsley Andrei I. Metelitsa Michael S. Kaminer 653

58 Botulinum toxin injections Christian Murray Nowell Solish 658

59 Oral mucosal therapeutics Ginat W. Mirowski Bethanee J. Schlosser 666

Part XII Major Adverse Effects from Systemic Drugs

60 Hepatotoxicity of dermatologic drug therapy Stephen E. Wolverton 677

61 Hematologic toxicity of drug therapy Kathleen A. Remlinger 690

62 Drug-induced malignancy Stephen E. Wolverton 701

63 Neurologic adverse effects from dermatologic drugs Mark A. Bechtel Henry K. Wong 711

64 Dermatologic drugs during pregnancy and lactation Katherine B. Lee Sancy A. Leachman 718

65 Drug interactions Lori E. Shapiro Neil H. Shear 730

66 Cutaneous drug reactions with systemic features Sandra R. Knowles Neil H. Shear 747

Part XIII Special Pharmacology and Therapeutic Topics

67 Pharmacoeconomics Marc A. Darst Jennifer Reddan Ashley N. Feneran 757

68 Informed consent and risk management Stephen E. Wolverton Marshall B. Kapp 766

69 Compounding in dermatology Linda F. McElhiney 771

70 Dermatologic drug therapy in children Brandie T. Styron Anita N. Haggstrom 778

Appendix I 787

Appendix II 792

Index 793

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