Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

by Eberhard O. Voit, Antonio E. Ferreira
     
 

ISBN-10: 052178087X

ISBN-13: 9780521780872

Pub. Date: 09/04/2000

Publisher: Cambridge University Press

A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book

Overview

A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book begins with representations of biochemical systems, provides guidelines for setting up models, details mathematical and computational methods of parameter estimation and model analysis, and connects to the modern literature with four detailed case studies. Every step is illustrated with examples and explored with accompanying PLAS software. The volume also features over 250 exercises with about one quarter fully or partially solved.

Product Details

ISBN-13:
9780521780872
Publisher:
Cambridge University Press
Publication date:
09/04/2000
Pages:
544
Product dimensions:
7.99(w) x 9.96(h) x 1.38(d)

Table of Contents

Preface; Introduction; 1. Graphical representation of biochemical systems; 2. Models of biochemical systems; 3. From maps to equations; 4. Computer simulation; 5. Parameter estimation; 6. Analytical steady-state evaluation; 7. Sensitivity analysis; 8. Case study 1 - Anaerobic fermentation pathway in Saccharomyces cerevisiae; 9. Case study 2 - diagnosis and refinement of a model of the tricarboxylic acid cycle in Dictyostelium discoideum; 10. Case study 3 - A sequence of models describing purine metabolism; 11. Case study 4 - Algebraic analysis of the initial steps of the Glycolytic-Glycogenolytic pathway in perfused rat liver; 12. Epilogue-Canonical modeling beyond biochemistry; Appendix; Hints and solutions; References; Author index; Subject index.

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