Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $69.97
Usually ships in 1-2 business days
(Save 69%)
Other sellers (Hardcover)
  • All (10) from $69.97   
  • New (6) from $173.94   
  • Used (4) from $69.97   


A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book begins with representations of biochemical systems, provides guidelines for setting up models, details mathematical and computational methods of parameter estimation and model analysis, and connects to the modern literature with four detailed case studies. Every step is illustrated with examples and explored with accompanying PLAS software. The volume also features over 250 exercises with about one quarter fully or partially solved.

Read More Show Less

Editorial Reviews

From the Publisher
"I found the introduction to this book absolutely fascinating...I enjoyed this book enormously. Having had to learn all this stuff on my own, I was happy to see it all (and more!) outlined in a single source. This book is unique in many ways...I highly recommend the book to scientists interested in dynamics/kinetics of complex systems." Journal of Food Biochemistry
Read More Show Less

Product Details

  • ISBN-13: 9780521780872
  • Publisher: Cambridge University Press
  • Publication date: 9/4/2000
  • Pages: 544
  • Product dimensions: 7.99 (w) x 9.96 (h) x 1.38 (d)

Table of Contents

Preface; Introduction; 1. Graphical representation of biochemical systems; 2. Models of biochemical systems; 3. From maps to equations; 4. Computer simulation; 5. Parameter estimation; 6. Analytical steady-state evaluation; 7. Sensitivity analysis; 8. Case study 1 - Anaerobic fermentation pathway in Saccharomyces cerevisiae; 9. Case study 2 - diagnosis and refinement of a model of the tricarboxylic acid cycle in Dictyostelium discoideum; 10. Case study 3 - A sequence of models describing purine metabolism; 11. Case study 4 - Algebraic analysis of the initial steps of the Glycolytic-Glycogenolytic pathway in perfused rat liver; 12. Epilogue-Canonical modeling beyond biochemistry; Appendix; Hints and solutions; References; Author index; Subject index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)