Computational Analysis of Biochemical Systems: A Practical Guide for Biochemists and Molecular Biologists

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Overview

"This book teaches biochemists and molecular biologists in a hands-on fashion the use of modern computational methods for the analysis of complex biomedical systems; a modest mathematical background will suffice. The book begins with representations of biochemical systems, provides guidelines for setting up models, discusses in detail mathematical and computational methods of parameter estimation and model analysis, and ultimately connects to the modern literature with four detailed case studies. Every step is illustrated with examples and exercises, and is explored with the accompanying software, PLAS. A dedicated Web site featuring color illustrations, further exercises, research news, as well as resources and links also accompanies this book."--BOOK JACKET.
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Editorial Reviews

From the Publisher
"I found the introduction to this book absolutely fascinating...I enjoyed this book enormously. Having had to learn all this stuff on my own, I was happy to see it all (and more!) outlined in a single source. This book is unique in many ways...I highly recommend the book to scientists interested in dynamics/kinetics of complex systems." Journal of Food Biochemistry
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Product Details

  • ISBN-13: 9780521780872
  • Publisher: Cambridge University Press
  • Publication date: 9/4/2000
  • Pages: 544
  • Product dimensions: 7.99 (w) x 9.96 (h) x 1.38 (d)

Table of Contents

Preface
Introduction 1
1 Graphical Representation of Biochemical Systems 11
2 Models of Biochemical Systems 37
3 From Maps to Equations 76
4 Computer Simulation 97
5 Parameter Estimation 143
6 Analytical Steady-State Evaluation 193
7 Sensitivity Analysis 222
8 Case Study 1 - Anaerobic Fermentation Pathway in Saccharomyces cerevisiae 260
9 Case Study 2 - Diagnosis and Refinement of a Model of the Tricarboxylic Acid Cycle in Dictyostelium discoideum 293
10 Case Study 3 - A Sequence of Models Describing Purine Metabolism 326
11 Case Study 4 - Algebraic Analysis of the Initial Steps of the Glycoltic-Glycogenolytic Pathway in Perfused Rat Liver 365
12 Epilogue - Canonical Modeling Beyond Biochemistry 399
Appendix 413
Hints and Partial Solutions 443
References 469
Author Index 499
Subject Index 507
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