Computational Genetics and Genomics: Tools for Understanding Disease / Edition 1

Computational Genetics and Genomics: Tools for Understanding Disease / Edition 1

by Gary Peltz
     
 

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ISBN-10: 1588291871

ISBN-13: 9781588291875

Pub. Date: 04/25/2005

Publisher: Springer-Verlag New York, LLC

This volume provides an overview and assessment of currently available and developing tools that will be used to identify the genetic basis for susceptibility to disease. Methods are presented for analyzing mouse genetic models of biomedically important traits.

Overview

This volume provides an overview and assessment of currently available and developing tools that will be used to identify the genetic basis for susceptibility to disease. Methods are presented for analyzing mouse genetic models of biomedically important traits.

Product Details

ISBN-13:
9781588291875
Publisher:
Springer-Verlag New York, LLC
Publication date:
04/25/2005
Edition description:
2005
Pages:
308
Product dimensions:
6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Part I. Theory and Technical Concept

Computational Biology: Are We There Yet?
Gary Peltz

Statistical Theory in QTL Mapping
Benjamin Yakir, Anne Pisanté, and Ariel Darvasi

Haplotype-Based Computational Genetic Analysis in Mice
Jianmei Wang and Gary Peltz

Haplotype Structure of the Mouse Genome
Jianmei Wang, Guochun Liao, Janet Cheng, Anh Nguyen, Jingshu Guo, Christopher Chou, Steven Hu, Sharon Jiang, John Allard, Steve Shafer, Anne Puech, John D. McPherson, Dorothee Foernzler, Gary Peltz, and Jonathan Usuka

SNP Discovery and Genotyping: Methods and Applications
Jun Wang, Dee Aud, Soren Germer, and Russell Higuchi

Part II. Selected Examples: Murine Models of Human Disease

Genetic and Genomic Approaches to Complex Lung Diseases Using Mouse Models
Michael J. Holtzman, Edy Y. Kim, and Jeffrey D. Morton

Murine Models of Osteoporosis
Robert F. Klein

Murine Models of Substance and Alcohol Dependence: Unraveling Genetic Complexities
Kim Cronise and John C. Crabbe

Murine Models of Alcoholism: From QTL to Gene
Chris Downing, Beth Bennett, and Thomas E. Johnson

Part III. Selected Examples: The Genetic Basis for Human Disease

HLA Polymorphism and Disease Susceptibility
Henry A. Erlich

Asthma Genetics: A Case Study
William Cookson

Index

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