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Computational Genetics and Genomics: Tools for Understanding Disease / Edition 1

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Overview

Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases. They also describe how genetic analysis of human populations has yielded information on the genetic basis for susceptibility to asthma and other inflammatory diseases.

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Product Details

  • ISBN-13: 9781617374098
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/16/2010
  • Edition description: Softcover reprint of hardcover 1st ed. 2005
  • Edition number: 1
  • Pages: 308

Table of Contents

Part I. Theory and Technical Concept

Computational Biology: Are We There Yet?
Gary Peltz

Statistical Theory in QTL Mapping
Benjamin Yakir, Anne Pisanté, and Ariel Darvasi

Haplotype-Based Computational Genetic Analysis in Mice
Jianmei Wang and Gary Peltz

Haplotype Structure of the Mouse Genome
Jianmei Wang, Guochun Liao, Janet Cheng, Anh Nguyen, Jingshu Guo, Christopher Chou, Steven Hu, Sharon Jiang, John Allard, Steve Shafer, Anne Puech, John D. McPherson, Dorothee Foernzler, Gary Peltz, and Jonathan Usuka

SNP Discovery and Genotyping: Methods and Applications
Jun Wang, Dee Aud, Soren Germer, and Russell Higuchi

Part II. Selected Examples: Murine Models of Human Disease

Genetic and Genomic Approaches to Complex Lung Diseases Using Mouse Models
Michael J. Holtzman, Edy Y. Kim, and Jeffrey D. Morton

Murine Models of Osteoporosis
Robert F. Klein

Murine Models of Substance and Alcohol Dependence: Unraveling Genetic Complexities
Kim Cronise and John C. Crabbe

Murine Models of Alcoholism: From QTL to Gene
Chris Downing, Beth Bennett, and Thomas E. Johnson

Part III. Selected Examples: The Genetic Basis for Human Disease

HLA Polymorphism and Disease Susceptibility
Henry A. Erlich

Asthma Genetics: A Case Study
William Cookson

Index

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