Computational Protein-Protein Interactions

by Ruth Nussinov (Editor), Gideon Schreiber (Editor)

Overview

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current resear

Product Details

ISBN-13:	9781040206553
Publisher:	CRC Press
Publication date:	06/26/2009
Sold by:	Barnes & Noble
Format:	eBook
Pages:	344
File size:	10 MB

About the Author

Ruth Nussinov, Gideon Schreiber

Table of Contents

Computational design of protein-protein interactions. Molecular Mimicry and Competitive Recruitment. Intrinsically unstructured proteins. The molecular architecture of protein-protein binding sites. Characteristic of protein-protein recognition. Protein-Protein Docking. Identification of hot spots within druggable binding regions. Hot-spot mimicry of ac cytokine receptor. Chaperone-related immune dysfunction. Recognition proteins of the innate immune system. Epitope mapping using combinatorial phage-display libraries. Identification of conserved protein complexes based on a model of protein network evolution. Interaction sites identified from sequences. Thermophilic Protein Complex Stabilized by Topological Interlinked. Protein interface recognition for structural proteomics. Strategies to search and design stabilizers of protein-protein interactions. Dynamics and allostery in protein-protein interactions.