Computational Protein-Protein Interactions / Edition 1

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A description of fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for predicting function. The text provides an overview of the topic with general chapters understandable by students and junior researches in this area, while also providing advanced material for more specialized readers. The chapters detail the complexity of protein interaction studies and inform readers of potential caveats that might be involved.

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Product Details

  • ISBN-13: 9781420070057
  • Publisher: Taylor & Francis
  • Publication date: 6/26/2009
  • Edition number: 1
  • Pages: 344
  • Product dimensions: 6.30 (w) x 9.40 (h) x 1.00 (d)

Table of Contents

Basic Principles of Protein–Protein Interaction, J. Janin
Low-Resolution Recognition Factors Determine Major Characteristics of the Energy Landscape in Protein–Protein Interaction, I.A. Vakser
The Molecular Architecture of Protein–Protein Binding Sites, E.J. Sundberg
Mapping Protein Function by Combinatorial Mutagenesis, G. Pál and S.S. Sidhu
The Association of Protein–Protein Complexes, G. Schreiber
Computational Simulations of Protein–Protein and Protein–Nucleic Acid Association, G.V. Pachov, R.R. Gabdoulline, and R.C. Wade
Computational Design of Protein–Protein Interactions, J.M. Shifman
Protein–Protein Docking, H. Hwang, B. Pierce, and Z. Weng
Prediction of Protein Interaction Sites, Y. Ofran
Predicting Molecular Interactions in Structural Proteomics, I. Kufareva and R. Abagyan
Rearrangements and Expansion of the Domain Content in Proteins Frequently Increase the Protein Connectivity in the Protein–Protein Interaction Network, I. Cohen-Gihon, R. Sharan, and R. Nussinov
Intrinsically Disordered Proteins and Their Recognition Functions, V.N. Uversky, M. Fuxreiter, C.J. Oldfield, A.K. Dunker, and P. Tompa
Identification of Druggable Hot Spots on Proteins and in Protein–Protein Interfaces, D. Beglov, R. Brenke, G.-Y. Chuang, D. Hall, M. Landon, C.H. Ngan, Y. Shen, S. Thiel, B. Zerbe, D. Kozakov, and S. Vajda
Designing Protein–Protein Interaction Inhibitors, M. Montes

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