Computer Analysis of Sequence Data, Part I
DNA sequencing has become increasingly efficient over the years, resulting in an enormous increase in the amount of data gen- ated. In recent years, the focus of sequencing has shifted, from being the endpoint of a project, to being a starting point. This is especially true for such major initiatives as the human genome project, where vast tracts of DNA of unknown function are sequenced. This sheer volume of available data makes advanced computer methods ess- tial to analysis, and a familiarity with computers and sequence ana- sis software a vital requirement for the researcher involved with DNA sequencing. Even for nonsequencers, a familiarity with sequence analysis software can be important. For instance, gene sequences already present in the databases can be extremely useful in the design of cloning and genetic manipulation experiments. This two-part work on Analysis of Data is designed to be a practical aid to the researcher who uses computers for the acquisition, storage, or analysis of nucleic acid (and/or p- tein) sequences. Each chapter is written such that a competent sci- tist with basic computer literacy can carry out the procedure successfully at the first attempt by simply following the detailed pr- tical instructions that have been described by the author. A Notes section, which is included at the end of each chapter, provides advice on overcoming the common problems and pitfalls sometimes enco- tered by users of the sequence analysis software. Software packages for both the mainframe and personal computers are described.
1108185323
Computer Analysis of Sequence Data, Part I
DNA sequencing has become increasingly efficient over the years, resulting in an enormous increase in the amount of data gen- ated. In recent years, the focus of sequencing has shifted, from being the endpoint of a project, to being a starting point. This is especially true for such major initiatives as the human genome project, where vast tracts of DNA of unknown function are sequenced. This sheer volume of available data makes advanced computer methods ess- tial to analysis, and a familiarity with computers and sequence ana- sis software a vital requirement for the researcher involved with DNA sequencing. Even for nonsequencers, a familiarity with sequence analysis software can be important. For instance, gene sequences already present in the databases can be extremely useful in the design of cloning and genetic manipulation experiments. This two-part work on Analysis of Data is designed to be a practical aid to the researcher who uses computers for the acquisition, storage, or analysis of nucleic acid (and/or p- tein) sequences. Each chapter is written such that a competent sci- tist with basic computer literacy can carry out the procedure successfully at the first attempt by simply following the detailed pr- tical instructions that have been described by the author. A Notes section, which is included at the end of each chapter, provides advice on overcoming the common problems and pitfalls sometimes enco- tered by users of the sequence analysis software. Software packages for both the mainframe and personal computers are described.
109.99 In Stock
Computer Analysis of Sequence Data, Part I

Computer Analysis of Sequence Data, Part I

Computer Analysis of Sequence Data, Part I

Computer Analysis of Sequence Data, Part I

Paperback(1994)

$109.99 
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Overview

DNA sequencing has become increasingly efficient over the years, resulting in an enormous increase in the amount of data gen- ated. In recent years, the focus of sequencing has shifted, from being the endpoint of a project, to being a starting point. This is especially true for such major initiatives as the human genome project, where vast tracts of DNA of unknown function are sequenced. This sheer volume of available data makes advanced computer methods ess- tial to analysis, and a familiarity with computers and sequence ana- sis software a vital requirement for the researcher involved with DNA sequencing. Even for nonsequencers, a familiarity with sequence analysis software can be important. For instance, gene sequences already present in the databases can be extremely useful in the design of cloning and genetic manipulation experiments. This two-part work on Analysis of Data is designed to be a practical aid to the researcher who uses computers for the acquisition, storage, or analysis of nucleic acid (and/or p- tein) sequences. Each chapter is written such that a competent sci- tist with basic computer literacy can carry out the procedure successfully at the first attempt by simply following the detailed pr- tical instructions that have been described by the author. A Notes section, which is included at the end of each chapter, provides advice on overcoming the common problems and pitfalls sometimes enco- tered by users of the sequence analysis software. Software packages for both the mainframe and personal computers are described.

Product Details

ISBN-13: 9780896032460
Publisher: Springer-Verlag New York, LLC
Publication date: 02/23/1994
Series: Methods in Molecular Biology , #24
Edition description: 1994
Pages: 372
Product dimensions: 5.83(w) x 8.27(h) x 0.03(d)

About the Author

Griffin, Annette M. (Norwich Research Park); Griffin, Hugh G. (Norwich Research Park)

The contributors represent the specialties of biology, cancer research, and food and nutrition research. They come from the U.K., Germany, U.S. and Switzerland. Institutions prominently represented include Institute of Cancer Research-U.K., Institute of Food Research-U.K., Norwich Research Park-U.K., and the Virginia Polytechnic Institute and State Univ.

Table of Contents

Computer Analysis of Sequence Data.- GCG: Fragment Assembly Programs.- GCG: Drawing Linear Restriction Maps.- GCG: Drawing Circular Restriction Maps.- GCG: Displaying Restriction Sites and Possible Translations in a DNA Sequence.- GCG: Assembly of Sequences into New Sequence Constructs.- GCG: Comparison of Sequences.- GCG: Production of Multiple Sequence Alignment.- GCG: Database Searching.- GCG: Pattern Recognition.- GCG: Translation of DNA Sequence.- GCG: Analysis of Protein Sequences.- GCG: The Analysis of RNA Secondary Structure.- GCG: Preparing Sequence Data for Publication.- MicroGenie: Introduction and Restriction Enzyme Analysis.- MIicroGenie: Shotgun DNA Sequencing.- MicroGenie: Translation.- MicroGenie: Protein Analysis.- MicroGenie: Homology Searches.- PC/GENE: Sequence Entry and Assembly.- PC/GENE: Restriction Enzyme Analysis.- PC/GENE: Translation and Searches for Protein Coding Regions.- PC/GENE: Sequence Comparisons and Homologies.- PC/GENE: Database Searches.- PC/GENE: Searches for Functional Sites in Nucleic Acids and Proteins.- Using the FASTA Program to Search Protein and DNA Sequence Databases.- Converting Between Sequence Formats.- Obtaining Software via INTERNET.- Submission of Nucleotide Sequence Data to EMBL/GenBank/DDBJ.
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