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Doody's Review ServiceReviewer: James M. Kramer, PhD (Northwestern University Feinberg School of Medicine)
Description: This book describes the use of computer programs contained in three protein/nucleic acid sequence analysis software packages: Staden, DNA Strider, and MacVector. Additionally, use of individual programs for prediction of RNA secondary structure, alignment of sequences, database searching and submission of sequences to the EMBL databank are described.
Purpose: The purpose of this book is to serve as a practical aid for scientists performing computer analyses of protein and/or nucleic acid sequences with these programs. It will help new users learn the programs more quickly and provides useful tips for experienced users.
Audience: The book is targeted at scientists involved in nucleic acid/protein sequence analysis, and who already have basic knowledge of the biology of these molecules. It will be particularly useful for those with little experience using these computer programs, but also contains information that experienced users will appreciate. The multiple authors are all acknowledged experts in the field of computer sequence analysis.
Features: Step-by-step descriptions of how to use the computer programs are provided. Numerous examples of output from the programs are presented as figures. Solutions to some problems commonly encountered with each program are provided at the end of each chapter.
Assessment: This is a very useful book for all researchers involved in computer analysis of protein and/or nucleic acid sequences. It collects in one place basic procedures for use of these computer programs that will aid inexperienced users. The book also provides details of the programs that will be valuable to experienced users.