Computer Techniques in Preclinical and Clinical Drug Development / Edition 1

Computer Techniques in Preclinical and Clinical Drug Development / Edition 1

by Robert C. Jackson, Jackson
     
 

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the… See more details below

Overview

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing. This new text asks the question, "How can we use computational methods to improve the success rate in drug development?" Computer Techniques in Preclinical and Clinical Drug Development shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

Product Details

ISBN-13:
9780849376825
Publisher:
Taylor & Francis
Publication date:
07/23/1996
Edition description:
New Edition
Pages:
256
Product dimensions:
6.30(w) x 9.50(h) x 0.80(d)

Table of Contents

Introduction: The Preclinical and Clinical Drug Development Process
Physiological Pharmacokinetic Modeling
Interspecies Scaling
Prediction of Drug Metabolism and Toxicity
Pharmacodynamic Modeling
Cytokinetic Modeling
Prediction of Drug Resistance
Conclusions: The Virtual Clinical Trial
References
Appendix: Computational Pharmacology Software Suppliers
Abbreviations
Index

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