Concepts in Biochemistry / Edition 2

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Overview

Rodney Boyer's text gives students a modern view of biochemistry. He utilizes a contemporary approach organized around the theme of nucleic acids as central molecules of biochemistry, with other biomolecules and biological processes treated as direct or indirect products of the nucleic acids.
The topical coverage usually provided in current biochemistry courses is all present - only the sense of focus and balance of coverage has been modified. The result is a text of exceptional relevance for students in allied-health fields, agricultural studies, and related disciplines.
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Product Details

  • ISBN-13: 9780534380069
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 4/28/2002
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 652

Table of Contents

Part I Molecules and Life 1
Chapter 1 Biochemistry: Setting the Stage 3
1.1 The Roots of Modern Biochemistry 5
1.2 Living Matter Contains C, H, O, N, P, and S 9
1.3 Biological Macromolecules 11
1.4 Organelles, Cells, and Organisms 13
Chapter 2 The Flow of Biological Information: Cell Communication 29
2.1 Storage of Biological Information in DNA 31
2.2 Transfer of Biological Information to RNA 34
2.3 Protein Synthesis 36
2.4 Errors in DNA Processing 39
2.5 Information Flow Through Cell membranes 40
2.6 Diseases of Cellular Communication and Drug Design 43
Chapter 3 Biomolecules in Water 47
3.1 Water, the Biological Solvent 49
3.2 Hydrogen Bonding and Solubility 52
3.3 Cellular Reactions of Water 55
3.4 Buffer Systems 61
Chapter 4 Amino Acids, Peptides, and Proteins 69
4.1 The Amino Acids in Proteins 70
4.2 Polypeptides and Proteins 78
4.3 Protein Function 79
4.4 Protein Size, Composition, and Properties 82
4.5 Four Levels of Protein Structure 84
4.6 Protein Primary Structure 84
Part II Dynamic Function of Biomolecules 95
Chapter 5 Protein Architecture and Biological Function 97
5.1 General Principles of Protein Design 98
5.2 Elements of Secondary Structure 102
5.3 Protein Tertiary Structure 107
5.4 Protein Quaternary Structure 110
5.5 Protein Structure and Biological Function 111
Chapter 6 Enzymes I: Reactions, Kinetics, and Inhibition 125
6.1 Enzymes As Biological Catalysts 126
6.2 The Kinetic Properties of Enzymes 130
6.3 Substrate Binding and Enzyme Action 136
6.4 Enzyme Inhibition 141
Chapter 7 Enzymes II: Coenzymes, Regulation, Abzymes, and Ribozymes 155
7.1 Enzyme: Coenzyme Partners 156
7.2 Allosteric Enzymes 161
7.3 Cellular Regulation of Enzymes 167
7.4 Site-Directed Mutagenesis and Abzymes 170
7.5 Ribozymes 172
Chapter 8 Carbohydrates: Structure and Biological Function 179
8.1 Monosaccharides 180
8.2 Carbohydrates in Cyclic Structures 182
8.3 Reactions of Monosaccharides 186
8.4 Polysaccharides 192
8.5 Glycoproteins 198
Chapter 9 Lipids, Biological Membranes, and Cellular Transport 207
9.1 Fatty Acids 209
9.2 Triacylglycerols 211
9.3 Polar Lipids 216
9.4 Steroids and Other Lipids 219
9.5 Biological Membranes 225
9.6 Membrane Transport 229
9.7 Examples of Membrane Transport 232
Part III Storage and Transfer of Biological Information 241
Chapter 10 DNA and RNA: Structure and Function 243
10.1 RNA and DNA Chemical Structures 244
10.2 DNA Structural Elements 251
10.3 RNA Structural Elements 258
10.4 Cleavage of DNA and RNA by Nucleases 261
10.5 Nucleic Acid-Protein Complexes 264
Chapter 11 DNA Replication and Transcription: Biosynthesis of DNA and RNA 271
11.1 Replication of DNA 272
11.2 Action of DNA Polymerases 277
11.3 DNA Damage and Repair 283
11.4 Synthesis of RNA 287
11.5 Post-transcriptional Modification of RNA 293
11.6 Base Sequences in DNA 298
Chapter 12 Translation of RNA: The Genetic Code and Protein Metabolism 305
12.1 The Process of Protein Synthesis 306
12.2 The Three Stages of Protein Synthesis 312
12.3 Post-Translational Processing of Proteins 320
12.4 Regulation of Protein Synthesis and Gene Expression 325
Chapter 13 Recombinant DNA and Other Topics in Biotechnology 337
13.1 Recombinant DNA Technology 338
13.2 Preparing Recombinant DNA 342
13.3 DNA Amplification by the Polymerase Chain Reaction 349
13.4 Applications of Recombinant DNA Technology 352
Part IV Metabolism and Energy 363
Chapter 14 Basic Concepts of Cellular Metabolism and Bioenergetics 365
14.1 Intermediary Metabolism 368
14.2 The Chemistry of Metabolism 372
14.3 Concepts of Bioenergetics 379
Chapter 15 Metabolism of Carbohydrates 393
15.1 The Energy Metabolism of Glucose 395
15.2 Entry of Other Carbohydrates into Glycolysis 400
15.3 Pyruvate Metabolism 403
15.4 Biosynthesis of Carbohydrates 406
15.5 Regulation of Carbohydrate Metabolism 413
Chapter 16 Production of NADH and NADPH: The Citric Acid Cycle, the Glyoxylate Cycle, and the Phosphogluconate Pathway 423
16.1 The Pyruvate Dehydrogenase Complex 425
16.2 The Citric Acid Cycle 433
16.3 The Citric Acid Cycle in Regulation and Biosynthesis 438
16.4 The Glyoxylate Cycle 441
16.5 The Phosphogluconate Pathway 443
Chapter 17 ATP Formation by Electron-Transport Chains 449
17.1 Mitochondrial Electron Transport 450
17.2 Components of the Electron-Transport Chain 454
17.3 Oxidative Phosphorylation 459
17.4 Recycling of Cytoplasmic NADH 463
17.5 Photosynthetic Electron Transport 465
17.6 Synthesis of Carbohydrates by the Calvin Cycle 478
Chapter 18 Metabolism of Fatty Acids and Lipids 487
18.1 Metabolism of Dietary Triacylglycerols 488
18.2 Catabolism of Fatty Acids 493
18.3 Biosynthesis of Fatty Acids 502
18.4 Cholesterol 507
18.5 Transport of Lipids in Blood 514
Chapter 19 Metabolism of Amino Acids and Other Nitrogenous Compounds 523
19.1 The Nitrogen Cycle 524
19.2 Biosynthesis of Amino Acids 528
19.3 Catabolism of Amino Acids 532
19.4 Elimination of NH[superscript + subscript 4] 538
19.5 Amino Acids as Precursors of Other Biomolecules 541
Chapter 20 Integration, Coordination, and Specialization in Metabolism 557
20.1 Overall Strategies of Metabolism 558
20.2 Metabolic Specialization and Integration 561
20.3 Metabolic Control by Hormones 566
20.4 Metabolic Responses to Stressful Conditions 568
20.5 Biochemical Factors in Obesity 571
Glossary 577
Answers to Study Exercises 589
Credits 615
Index 617
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