Concepts in Clinical Pharmacokinetics / Edition 5

Concepts in Clinical Pharmacokinetics / Edition 5

by Joseph DiPiro
     
 

ISBN-10: 1585282413

ISBN-13: 9781585282418

Pub. Date: 01/01/2010

Publisher: American Society of Health-Systems Pharmacists


The past four editions of Concepts in Clinical Pharmacokinetics have helped simplify a complex subject for thousands of pharmacy students and practitioners. The new, fifth edition of this popular teaching and self-instructional text makes it easier than ever to acquire a strong foundation in the basic principles of pharmacokinetics. The fundamental concepts…  See more details below

Overview


The past four editions of Concepts in Clinical Pharmacokinetics have helped simplify a complex subject for thousands of pharmacy students and practitioners. The new, fifth edition of this popular teaching and self-instructional text makes it easier than ever to acquire a strong foundation in the basic principles of pharmacokinetics. The fundamental concepts along with mathematical equations are broken down to their simplest forms and a step-by-step approach is adopted to explain the “how to” of this discipline.

Completely reviewed and updated, the new edition includes all of the features that have made previous editions so effective and popular, plus many enhancements:

  • 15 lessons ideal for a 15-week semester course and/or self-study, each designed to build comprehension and mastery step-by-step
  • Self-assessment questions and practice calculations
  • Additional case studies, plus expansion of existing cases to include sections on monitoring parameters and appropriate “order writing.”
  • More clinical correlates, plus an expanded “cross-correlates” section for easy cross-referencing
  • An extensive new section of assessments of renal function
  • An expanded appendix summarizing the basic pharmacokinetic functions, and listing all equations needed to dose selected drugs
  • More in-depth answers and detailed feedback for incorrect responses
  • New graphics focus on relevant components of equations under discussion

The goal of this book remains the same - to provide the student or practitioner with the concepts and clinical applications needed for a better understanding of this complicated yet useful subject.

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Product Details

ISBN-13:
9781585282418
Publisher:
American Society of Health-Systems Pharmacists
Publication date:
01/01/2010
Pages:
248
Product dimensions:
8.50(w) x 10.70(h) x 0.50(d)

Related Subjects

Table of Contents

Contents
Acknowledgments vii
Preface ix
Abbreviations xi
Lessons and Practice Sets
Lesson 1.
Introduction to Pharmacokinetics and Pharmacodynamics 1
Lesson 2.
Basic Pharmacokinetics 19
Lesson 3.
Half-Life, Elimination Rate, and AUC 29
Practice Set 1
43
Lesson 4.
Intravenous Bolus Administration, Multiple Drug
Administration, and Steady-State Average Concentrations 45
Lesson 5.
Relationships of Pharmacokinetic Parameters and
Intravenous Intermittent and Continuous Infusions 59
Lesson 6.
Two-Compartment Models 73
Practice Set 2
83
Lesson 7.
Biopharmaceutics: Absorption 87
Lesson 8.
Drug Distribution and Protein Binding 103
Lesson 9.
Drug Elimination Processes 113
Lesson 10.
Nonlinear Processes 131
vi Contents
Lesson 11.
Pharmacokinetic Variation and Model-Independent
Relationships 141
Practice Set 3
155
Lesson 12.
Aminoglycosides 159
Lesson 13.
Vancomycin 179
Lesson 14.
Theophylline 195
Lesson 15.
Phenytoin and Digoxin 203
Appendix A.
Basic and Drug-Specific Pharmacokinetic Equations 217
Appendix B.
Supplemental Problems 225
Appendix C.
Glossary 231
Index
233

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