Concepts in Clinical Pharmacokinetics / Edition 5

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The past four editions of Concepts in Clinical Pharmacokinetics have helped simplify a complex subject for thousands of pharmacy students and practitioners. The new, fifth edition of this popular teaching and self-instructional text makes it easier than ever to acquire a strong foundation in the basic principles of pharmacokinetics. The fundamental concepts along with mathematical equations are broken down to their simplest forms and a step-by-step approach is adopted to explain the “how to” of this discipline.

Completely reviewed and updated, the new edition includes all of the features that have made previous editions so effective and popular, plus many enhancements:

  • 15 lessons ideal for a 15-week semester course and/or self-study, each designed to build comprehension and mastery step-by-step
  • Self-assessment questions and practice calculations
  • Additional case studies, plus expansion of existing cases to include sections on monitoring parameters and appropriate “order writing.”
  • More clinical correlates, plus an expanded “cross-correlates” section for easy cross-referencing
  • An extensive new section of assessments of renal function
  • An expanded appendix summarizing the basic pharmacokinetic functions, and listing all equations needed to dose selected drugs
  • More in-depth answers and detailed feedback for incorrect responses
  • New graphics focus on relevant components of equations under discussion

The goal of this book remains the same - to provide the student or practitioner with the concepts and clinical applications needed for a better understanding of this complicated yet useful subject.

This edition is accompanied by a Web-based version that will provide lessons to parallel each of the lessons in this book.

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Editorial Reviews

Doody's Review Service
Reviewer: Melissa M. Ranieri, BS, PharmD (Temple University School of Pharmacy)
Description: This is a basic introduction to pharmacokinetic calculations and concepts.
Purpose: The book is intended to introduce pharmacokinetic concepts in a manner that is easy to comprehend and apply to clinical dosing. Information is presented in a step-by-step approach with cases for practice. The nonintimidating approach to communicating basic pharmacokinetic theory is important for students or clinicians hoping to refine their skills in this area.
Audience: This would be helpful for students in a clinical pharmacokinetic course looking for additional references. Additionally, chapters are well designed for busy practitioners hoping to find a fast solution in clinical practice. Regardless of who is using this book, the theory is outlined in a refreshing manner that is interesting and easy to comprehend. It makes learning pharmacokinetics enjoyable instead of unattainable.
Features: The chapters use a step-by-step approach. Calculations are presented in case examples with accompanying solutions. Each equation is laid out so that individual parameters are clearly defined. Rationales are included in the solutions to the cases to help readers understand the answers. In this way, readers can better comprehend the theory behind the mathematical equation and more fully understand the pharmacokinetics. Graphs throughout the chapters help to reinforce concepts, as do clinical correlate boxes, which highlight important concepts. Finally, certain equations are circled to show readers calculations that may be more calculator-friendly or to emphasize when unit conversions are necessary.
Assessment: This is an excellent reference for students or practitioners looking for an understanding of basic pharmacokinetic concepts and equations, as well as application to drugs such as vancomycin, aminoglycosides, phenytoin, digoxin and theophylline. The step-by-step approach is easy to understand. Explanations are clear and key concepts are reinforced. Cases provide practice for readers to perform pharmacokinetic calculations and to apply pharmacokinetic concepts. The book succeeds in communicating pharmacokinetic theory, which is sometimes perceived as intimidating, in a way that is easy to understand.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781585282418
  • Publisher: American Society of Health-Systems Pharmacists
  • Publication date: 1/1/2010
  • Edition number: 5
  • Pages: 248
  • Product dimensions: 8.50 (w) x 10.70 (h) x 0.50 (d)

Meet the Author

Joseph T. DiPiro, Pharm.D.
Dr. Joseph T. DiPiro is Executive Dean of the South Carolina College of Pharmacy, which is an intergrated program of the Colleges of Pharmacy at the University of South Carolina and the Medical University of South Carolina. Before coming to South Carolina, Dr. DiPiro was the Panoz Professor of Pharmacy at the University of Georgia College of Pharmacy and Clinical Professor of Surgery at the Medical College of Georgia. While there, he was also Assistant Dean for the College of Pharmacy and the School of Medicine at the Medical College of Georgia, and Head, Department of Clinical and Administrative Pharmacy. He received his BS in pharmacy from the University of Connecticut and Doctor of Pharmacy from the University of Kentucky. He served a residency at the University of Kentucky Medical Center and a fellowship in Clinical Immunology at Johns Hopkins University.
He is the Editor of The American Journal of Pharmaceutical Education. Dr. DiPiro has published over 120 refereed papers in academic and professional journals, mainly related to antibiotics, drug use in surgery, various issues in pharmacy practice, and pharmacy education. His papers have appeared in Antimicrobial Agents and Chemotherapy, Pharmacotherapy, Critical Care Medicine, JAMA, Annals of Surgery, Archives of Surgery, American Journal of Surgery, Journal of Pharmacology and Experimental Therapeutics, and Surgical Infections.  He is the senior editor for Pharmacotherapy: A Pathophysiologic Approach, now in its 6th edition. He is also the author of Concepts in Clinical Pharmacokinetics and Editor of the Encyclopedia of Clinical Pharmacy. He serves on the editorial boards of Pharmacotherapy and American Surgeon.
He was a President of the American College of Clinical Pharmacy. He is a Fellow of the College and has served on the Research Institute Board of Trustees. He has been a member of the Surgical Infection Society Therapeutic Agents Committee and the American Society of Health-System Pharmacists, having served on the Commission on Therapeutics and the Task Force on Science. In 2002, the American Association of Colleges of Pharmacy selected Dr. DiPiro for the Robert K. Chalmers Distinguished Educator Award. He has also received the Russell R. Miller Literature Award and the Education Award from the American College of Clinical Pharmacy, the Award for Sustained Contributions to the Literature from the American Society of Health-System Pharmacists.
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Table of Contents

Acknowledgments vii
Preface ix
Abbreviations xi
Lessons and Practice Sets
Lesson 1.
Introduction to Pharmacokinetics and Pharmacodynamics 1
Lesson 2.
Basic Pharmacokinetics 19
Lesson 3.
Half-Life, Elimination Rate, and AUC 29
Practice Set 1
Lesson 4.
Intravenous Bolus Administration, Multiple Drug
Administration, and Steady-State Average Concentrations 45
Lesson 5.
Relationships of Pharmacokinetic Parameters and
Intravenous Intermittent and Continuous Infusions 59
Lesson 6.
Two-Compartment Models 73
Practice Set 2
Lesson 7.
Biopharmaceutics: Absorption 87
Lesson 8.
Drug Distribution and Protein Binding 103
Lesson 9.
Drug Elimination Processes 113
Lesson 10.
Nonlinear Processes 131
vi Contents
Lesson 11.
Pharmacokinetic Variation and Model-Independent
Relationships 141
Practice Set 3
Lesson 12.
Aminoglycosides 159
Lesson 13.
Vancomycin 179
Lesson 14.
Theophylline 195
Lesson 15.
Phenytoin and Digoxin 203
Appendix A.
Basic and Drug-Specific Pharmacokinetic Equations 217
Appendix B.
Supplemental Problems 225
Appendix C.
Glossary 231

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