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Concepts in Gene Therapy

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Product Details

  • ISBN-13: 9783110149845
  • Publisher: De Gruyter, Walter, Inc.
  • Publication date: 10/28/1997
  • Pages: 553
  • Product dimensions: 7.12 (w) x 9.60 (h) x 1.21 (d)

Table of Contents

I Methods of Gene Delivery
1 Retroviral Vectors 3
2 Adenoviral Vectors 25
3 Herpes Simplex Virus Mediated Gene Transfer to Neurons 43
4 Adeno-Associated Viral Vectors 61
5 Virus Functions for Artificial Vectors 79
6 Targeted Gene Delivery and Expression in Hepatocytes 99
7 Particle-Mediated Gene Delivery System for Cancer Research 109
II Methods for Inactivation or Restoration of Gene Function
8 Gene Inactivation by Homologous Recombination - Animal Models of Plasma Lipoprotein Disorders 123
9 Potential Antisense Oligonucleotide Therapies for Neurodegenerative Diseases 141
10 Synthetic Ribozymes: The Hammerhead Ribozyme 169
11 Ribozymes as Tools for the Gene Therapist 197
III Cellular Target Systems
12 Gene Transfer and Transgene Expression in Hematopoietic Cells 233
13 The Liver as a Target for Gene Therapy 267
14 Gene Therapy for Gaucher Disease via Genetically Engineered Primary Myoblasts 283
15 In vivo Secretion of Therapeutic Proteins from Neo-Organs 297
IV Genetic Diseases
16 Gene Therapy for Cystic Fibrosis - Strategies, Problems and Perspectives 315
17 Gene Therapy for Dystrophin Deficiency 347
18 Gene Therapy For Familial Hypercholesterolemia 359
19 Therapeutic Strategies for the Lysosomal Storage Disorders 387
V Non-Genetic and Infectious Diseases
20 Gene Therapy for Arthritis 417
21 Gene Therapy for HIV-1 Disease 431
VI Cancer
22 Suicide Genes for the Treatment of Cancer 469
23 Tumor Cell Vaccines Using Genetically Modified Cells Coexpressing Cytokines and the T Cell Costimulatory Molecule B7 487
24 Dosage Impact on Immunotherapy with Cytokine-Gene Modified Cancer Vaccines 505
25 Tumor Suppressor Gene Therapy - Growth Arrest and Programmed Cell Death 521
Contributors 539
Index 547
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