Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins / Edition 2

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The long-awaited Second Edition of this best-selling Concise Guide is here. Like the first edition of this unique pocket reference, the second edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive website references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, drug interaction assessment and prescribing guidelines, and medicolegal issues.

Following Part I, a succinct review of pharmacology, Part II contains pertinent tables, short reviews, and carefully chosen clinical and research illustrations (with case vignettes) for each P450 enzyme. In Part III, unique to this guide, the drugs used commonly in nonpsychiatric medicine that have clinically significant pharmacokinetic phase I, phase II, or P-glycoprotein drug interactions are arranged by specialty and listed in tables. Part IV focuses on practical matters, with chapters on drug interaction assessment and prescribing guidelines, medicolegal issues, and review and retrieval of the literature.

To enhance clinicians' use of this guide as a quick reference, the authors provide a pocket guide to the most common and potent inhibitors and inducers of drug metabolism, by enzyme system and by medical specialty.

Designed to enable psychiatrists to develop individualized tables and references for their own practices, this concise "how-to" guide will prove indispensable for students and practitioners in psychiatric (especially in complicated medical/surgical settings, such asgeriatrics) and nonpsychiatric (primary care, family practice, internal medicine, and obstetrics/gynecology) specialties alike.

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Editorial Reviews

Doody's Review Service
Reviewer: Brett C. Plyler, M.D.(Northwestern Memorial Hospital)
Description: This second edition is written to provide a broader range of accessible, practical information to psychiatrists about drug interactions in the cytochrome P450 system for a variety of different clinical settings.
Purpose: The second edition has been written to provide a broader scope to the understanding of pharmacokinetic drug interactions and their possible side effects involving the cytochrome P450 system, UGT's, and P-glycoprotiens. It is meant to be a pocket reference guide for psychiatrists on these subjects.
Audience: This book is written for psychiatric residents and attendings who want to better understand the cytochrome P450 system and the multiplicity of drug interactions that can occur within it.
Features: The book provides an examination of the chemical machinations of each prominent enzyme of the P450 system, the UGT's, and the P-glycoproteins, and then proceeds to examine the metabolism of important medications within a number of clinical specialties. It contains numerous tables describing which enzyme system metabolizes a particular medication and which medications may inhibit or induce certain enzyme systems. Furthermore, there is a separate pocket guide with these tables and other relevant information listed. It has numerous, up-to-date references at the end of each section that provide ample opportunity for further research if desired.
Assessment: This book presents the difficult topic of the P450 system and drug interactions in a practical, straightforward manner. Though it does become complex in some discussions of the chemical interactions, the reader should feel competent and comfortable when dealing with drug interactions of this nature after completing the book. This is an invaluable reference tool to an inpatient or consult psychiatrist, and would be a necessary addition to an outpatient psychiatrist's library. The pocket guide is helpful in providing quick reference tables of metabolizers, inducers, and inhibitors of each enzyme and medication. Finally, this second edition expanded the scope of the book and provides needed updates on new medications and research.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781585621118
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 1/28/2003
  • Edition description: Second Edition
  • Edition number: 2
  • Pages: 644
  • Product dimensions: 4.25 (w) x 6.50 (h) x 1.25 (d)

Meet the Author

Kelly L. Cozza, M.D., is a Psychiatrist at the Infectious Disease Service, Department of Medicine, at the Walter Reed Army Medical Center in Washington, D.C.; Assistant Professor at the Department of Psychiatry, Uniformed Services University of the Health Sciences in Bethesda, Maryland; and Fellow of the Academy of Psychosomatic Medicine. Dr. Cozza is the Med-Psych Drug-Drug Interactions Update co-editor of Psychosomatics.

Scott C. Armstrong, M.D., is Co-Medical Director at the Center for Geriatric Psychiatry, Tuality Forest Grove Hospital in Forest Grove, Oregon; Clinical Associate Professor of Psychiatry at Oregon Health and Science University in Portland; and Fellow of the American Psychiatric Association and the Academy of Psychosomatic Medicine. He has published many articles on various psychiatric subjects and is a peer reviewer for Military Medicine and Psychosomatics, as well as the Med-Psych Drug-Drug Interactions Update Editor of Psychosomatics.

Jessica R. Oesterheld, M.D., is Medical Director of The Spurwink School in Portland, Maine, and an Instructor in Family Medicine at the University of New England School of Osteopathy in Biddeford, Maine.

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Table of Contents

Introduction and Basic Pharmacology of Metabolic Drug Interactions. Introduction to drug interactions and to this concise guide. Definitions and phase I metabolism. Metabolism in depth: phase II. P-Glycoproteins. P450 Enzymes. 2D6. 3A4. 1A2. 2C9. 2C19. 2E1. P450 enzymes: 2A6, 2B6, 2C8. Drug Interactions by Medical Specialty. Gynecology: oral contraceptives. Internal medicine. Infectious diseases. Neurology. Oncology. Pain management I: nonnarcotic analgesics. Pain management II: narcotic analgesics. Psychiatry. Transplant surgery/rheumatology: immunosuppressants. Practical Matters. Guidelines. Medicolegal implications of drug-drug interactions. How to retrieve and review the literature. Appendix: trade and generic names used in this book. Index. Pull-out guide.

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Customer Reviews

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  • Anonymous

    Posted October 30, 2012

    not what I was expecting

    I didn't realize that that the Concise Guide was actually the full book - although I should have gathered that from the word "Concise." I can't give it a bad star rating since I didn't end up keeping it. We wanted to order the full book and not the small copy. Just a heads up if you are looking for the same. Still haven't found a good place to order the actual book from. Sellers aren't always dependable on B&N.

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