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Doody's Review ServiceReviewer: Brett C. Plyler, M.D.(Northwestern Memorial Hospital)
Description: This second edition is written to provide a broader range of accessible, practical information to psychiatrists about drug interactions in the cytochrome P450 system for a variety of different clinical settings.
Purpose: The second edition has been written to provide a broader scope to the understanding of pharmacokinetic drug interactions and their possible side effects involving the cytochrome P450 system, UGT's, and P-glycoprotiens. It is meant to be a pocket reference guide for psychiatrists on these subjects.
Audience: This book is written for psychiatric residents and attendings who want to better understand the cytochrome P450 system and the multiplicity of drug interactions that can occur within it.
Features: The book provides an examination of the chemical machinations of each prominent enzyme of the P450 system, the UGT's, and the P-glycoproteins, and then proceeds to examine the metabolism of important medications within a number of clinical specialties. It contains numerous tables describing which enzyme system metabolizes a particular medication and which medications may inhibit or induce certain enzyme systems. Furthermore, there is a separate pocket guide with these tables and other relevant information listed. It has numerous, up-to-date references at the end of each section that provide ample opportunity for further research if desired.
Assessment: This book presents the difficult topic of the P450 system and drug interactions in a practical, straightforward manner. Though it does become complex in some discussions of the chemical interactions, the reader should feel competent and comfortable when dealing with drug interactions of this nature after completing the book. This is an invaluable reference tool to an inpatient or consult psychiatrist, and would be a necessary addition to an outpatient psychiatrist's library. The pocket guide is helpful in providing quick reference tables of metabolizers, inducers, and inhibitors of each enzyme and medication. Finally, this second edition expanded the scope of the book and provides needed updates on new medications and research.