Conformational Proteomics of Macromolecular Architecture: Approaching the Structure of Large Molecular Assemblies and Their Mechanisms of Action (with Cd-Rom)

Hardcover (Print)


The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.
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Product Details

  • ISBN-13: 9789812386144
  • Publisher: World Scientific Publishing Company, Incorporated
  • Publication date: 6/28/2004
  • Pages: 432
  • Product dimensions: 6.20 (w) x 9.20 (h) x 0.90 (d)

Table of Contents

Pt. I Geometry and action in viruses 1
Ch. 1 Early theories of virus structure 3
Ch. 2 Quasi-equivalence and adaptability in living molecular assemblies 41
Ch. 3 The role of disordered segments in viral coat proteins 53
Ch. 4 Perfusion dynamics in an enveloped virus - alphavirus model 78
Pt. II Approaching large assembles in membranes 109
Ch. 5 Strategy to obtain high resolution structure of membrane proteins by x-ray crystallography 111
Ch. 6 On the possibility of determining structures of membrane proteins in two-dimensional crystals using x-ray free electron lasers 133
Ch. 7 Functional details on membrane proteins observed through an electron beam 148
Pt. III Protein shuttle 159
Ch. 8 Clathrin and companions 161
Pt. IV Giant enzymes 169
Ch. 9 Multifunctional enzyme complexes : multistep catalysis by molecular machines 171
Ch. 10 Metamorphosis of an enzyme 198
Ch. 11 Optimizing an enzyme for its physiological role : structural and functional comparisons of ATP sulfurylases from three different organisms 222
Pt. V Ribosomes 243
Ch. 12 Ribosomal crystallography : dynamics, flexibility and peptide bond formation 245
Ch. 13 The dynamics of the ribosome as inferred by cryo-EM : induced and self-organized motions 291
Ch. 14 How do translation factors catalyze protein synthesis 307
Pt. VI Motion engines 331
Ch. 15 Dynamic aspects of the bacterial flagellum 333
Ch. 16 Myosin polymorphism and muscle contraction 345
Pt. VII Around the bench proteomics 359
Ch. 17 Is crystallization a "bottleneck" of modern structural crystallomic? 361
Ch. 18 Sensor surface interactions in the study of macromolecular assemblies 379
Ch. 19 PPiDB - a protein-protein interactions database 391
Ch. 20 Virus particle explorer (VIPER) : a repository of virus capsid structures 403
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