Contemporary Drug Synthesis / Edition 1

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Overview

Drug synthesis comprises the heart of the pharmaceutical business today. Both in early development (identifying and optimizing a lead) as well as in process development (scale-up), the ability to develop elegant and economical synthetic routes proves tantamount to the commercial success of a drug. This book, authored by prominent scientists working in drug discovery, provides a useful guide for practicing pharmaceutical scientists, as well as a text for medicinal chemistry students.

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Editorial Reviews

From the Publisher
“…the authors have made an excellent selection of drugs and the coverage of the synthetic chemistry employed in their production is exemplary…” (Chemistry & Industry, 5th September 2005)

"…a clear and easy to use reference for anyone working in drug discovery and development." (E-STREAMS, January 2005)

"...a very useful book...for...pharmaceutical industry scientists...[and] the larger medicinal and organic chemistry community..." (Journal of Medicinal Chemistry, November 18, 2004)

"…an outstanding primer on methods for chemical drug synthesis…the test is most useful, well written, and serves as a useful read for those interested in drug synthesis." (American Journal of Therapeutics, September/October 2004)

“…highly interesting…keeps to the facts…” (www.organische-chemie.ch)

‘…I warmly recommend this book to synthetic organic chemists both in industry and in academia.' (Organic Process Research and Development Journal, July 2007)

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Product Details

  • ISBN-13: 9780471214809
  • Publisher: Wiley
  • Publication date: 6/25/2004
  • Series: Wiley Series on Drug Synthesis Series
  • Edition number: 1
  • Pages: 240
  • Product dimensions: 7.70 (w) x 9.67 (h) x 0.67 (d)

Meet the Author

JIE-JACK LI, PhD, DOUGLAS S. JOHNSON, PhD, DRAGO R. SLISKOVIC, PhD, AND BRUCE D. ROTH, PhD, are all members of Pfizer Global Research and Development, and are among the most prominent scientists working in drug discovery today.

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Table of Contents

Preface.

Trade Names and Their Corresponding USANs.

Acronyms and Abbreviations.

Chapter 1. Antithrombotics: Ticlopidine (Ticlid®) and Clopidogrel (Plavix®).

Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex®) and Rofecoxib (Vioxx®).

Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium®).

Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec®) and Gefitinib (Iressa®).

Chapter 5. Non-sedating Antihistamines.

Chapter 6. Cosmeceuticals: Istretinoin (Accutane®), Tazarotene (Tazorac®), Minoxidil (Rogaine®), and Finasteride (Propecia®).

Chapter 7. Antibacterials: Ciprofloxacin (Cipro®) and Linezolid (Zyvox®).

Chapter 8. Atypical Antupsychotics.

Chapter 9. Atovastatin Calcium (Lipitor®).

Chapter 10. Antidepressants.

Chapter 11. Anti-obesity: Orlistat (Xenical®).

Chapter 12. Triptans for Migrane.

Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra®), Vardenafil (Levitra®), and Tadalafil (Cialis®).

Chapter 14. Antiasthmatics.

Index.

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