Contemporary Drug Synthesis / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $91.15
Usually ships in 1-2 business days
(Save 39%)
Other sellers (Hardcover)
  • All (6) from $91.15   
  • New (5) from $91.15   
  • Used (1) from $122.11   


Drug synthesis comprises the heart of the pharmaceutical business today. Both in early development (identifying and optimizing a lead) as well as in process development (scale-up), the ability to develop elegant and economical synthetic routes proves tantamount to the commercial success of a drug. This book, authored by prominent scientists working in drug discovery, provides a useful guide for practicing pharmaceutical scientists, as well as a text for medicinal chemistry students.

Read More Show Less

Editorial Reviews

From the Publisher
“…the authors have made an excellent selection of drugs and the coverage of the synthetic chemistry employed in their production is exemplary…” (Chemistry & Industry, 5th September 2005)

"…a clear and easy to use reference for anyone working in drug discovery and development." (E-STREAMS, January 2005)

"...a very useful book...for...pharmaceutical industry scientists...[and] the larger medicinal and organic chemistry community..." (Journal of Medicinal Chemistry, November 18, 2004)

"…an outstanding primer on methods for chemical drug synthesis…the test is most useful, well written, and serves as a useful read for those interested in drug synthesis." (American Journal of Therapeutics, September/October 2004)

“…highly interesting…keeps to the facts…” (

‘…I warmly recommend this book to synthetic organic chemists both in industry and in academia.' (Organic Process Research and Development Journal, July 2007)

Read More Show Less

Product Details

  • ISBN-13: 9780471214809
  • Publisher: Wiley
  • Publication date: 6/25/2004
  • Series: Wiley Series on Drug Synthesis Series
  • Edition number: 1
  • Pages: 240
  • Product dimensions: 7.70 (w) x 9.67 (h) x 0.67 (d)

Meet the Author

JIE-JACK LI, PhD, DOUGLAS S. JOHNSON, PhD, DRAGO R. SLISKOVIC, PhD, AND BRUCE D. ROTH, PhD, are all members of Pfizer Global Research and Development, and are among the most prominent scientists working in drug discovery today.

Read More Show Less

Table of Contents


Trade Names and Their Corresponding USANs.

Acronyms and Abbreviations.

Chapter 1. Antithrombotics: Ticlopidine (Ticlid®) and Clopidogrel (Plavix®).

Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex®) and Rofecoxib (Vioxx®).

Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium®).

Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec®) and Gefitinib (Iressa®).

Chapter 5. Non-sedating Antihistamines.

Chapter 6. Cosmeceuticals: Istretinoin (Accutane®), Tazarotene (Tazorac®), Minoxidil (Rogaine®), and Finasteride (Propecia®).

Chapter 7. Antibacterials: Ciprofloxacin (Cipro®) and Linezolid (Zyvox®).

Chapter 8. Atypical Antupsychotics.

Chapter 9. Atovastatin Calcium (Lipitor®).

Chapter 10. Antidepressants.

Chapter 11. Anti-obesity: Orlistat (Xenical®).

Chapter 12. Triptans for Migrane.

Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra®), Vardenafil (Levitra®), and Tadalafil (Cialis®).

Chapter 14. Antiasthmatics.


Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)