Contemporary Issues in Modeling Psychopathology / Edition 1

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Overview

Despite considerable progress in clinical and basic neurosciences, the cure of psychiatric disorders is still remote, little is known about their prevention, and the etiology and molecular mechanisms of mental disorders are still obscure. Diagnoses are still guided by patients' stories. The mission of animal models is to bridge the gap between 'the story and the synapse.' Contemporary Issues in Modeling of Psychopathology attempts to do this by examining such questions as 'What good might come from such a model? Are we wasting our time? How far can we carry results from model animals, such as rats and mice, without causing a highly distorted view of the field and its goals?'
This book serves as the opening volume for a new series, Neurobiological Foundation of Aberrant Behaviors.

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Product Details

Table of Contents

1 Involvement of Dopamine Transporters in Psychiatric Disorders 1
2 The Long-Term Behavioral and Neurobiological Consequences of Treatment with Psychomotor Stimulant Drugs: Implications for Psychopathology 19
3 Anxiety and Impulse Control in Rats Selectively Bred for Seizure Susceptibility 29
4 Behavioral and Neurohormonal Sequelae of Prenatal Stress: a Suggested Model of Depression 45
5 Promises and Limitations of Transgenic and Knockout Mice in Modeling Psychiatric Symptoms 55
6 Viral Mechanisms of Schizophrenia 79
7 Prepulse Inhibition as a Cross-Species Model of Sensorimotor Gating Deficits in Schizophrenia 103
8 Neural Systems Involved in Fear Inhibition: Extinction and Conditioned Inhibition 113
9 Brian Laterality as a Source of Individual Differences in Behavior: Animal Models of Depression and Substance Abuse 143
10 Animal Models of Bipolar Disorder: From a Single Episode to Progressive Cycling Models 165
11 Emergence of PTSD-type Reactivity in Sprague-Dawley Rats Following Prenatal Gamma Irradiation 181
12 The Latent Inhibition Model of Schizophrenia 197
13 Rat Latent Inhibition and Prepulse Inhibition are Sensitive to Different Manipulations of the Social Environment: A Comprehensive Study of the Environmental Approach to Neurodevelopmental Models of Schizophrenia 231
14 Animal Models of Set-Formation and Set-Shifting Deficits in Schizophrenia 247
15 Early Disruption of Corticolimbic Circuitry as a Model of Schizophrenia 259
16 Coping with Uncertainty: What Would an Animal Model of Schizophrenia Look Like? 275
17 Models of Psychoses: Which One, When, and Why? 293
Index 313
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