Control of Biofilm Infections by Signal Manipulation / Edition 1

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The medical miracle of antibiotics is being eroded by the emergence and spread of bacterial drug resistance. This is compounded by the fact that bacterial biofilms are believed to be a common cause of persistent infections, where growing in a biofilm, bacteria are protected from the host's immune response and antibiotics. Biofilms can spawn systemic infections by sloughing off planktonic bacteria, leading to dissemination, bacteremia, sepsis, and death. The number of patients affected by and dying from what can be considered as a "biofilm disease" is higher than heart disease and cancer combined, making medical biofilms the biggest single disease that the healthcare system is facing today. This book describes the molecular mechanisms of bacterial cell-to-cell communication (quorum sensing), the development of anti-biofilm inhibitors, and the use of such inhibitors to prevent and treat biofilm-associated bacterial infections in animals and humans.

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Product Details

  • ISBN-13: 9783642093098
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 11/19/2010
  • Series: Springer Series on Biofilms, #2
  • Edition description: Softcover reprint of hardcover 1st ed. 2008
  • Edition number: 1
  • Pages: 175
  • Product dimensions: 6.10 (w) x 9.11 (h) x 0.43 (d)

Table of Contents

Introduction   Naomi Balaban   Dacheng Ren   Michael Givskov   Thomas Bovbjerg Rasmussen     1
Bacterial Cell-to-cell Communication (Quorum Sensing)   Michael Givskov   Thomas Bovbjerg Rasmussen   Dacheng Ren   Naomi Balaban     13
Detection In Vitro of Quorum-Sensing Molecules and Their Inhibitors   Robert J.C. McLean   Sandra A. Bryant   Dhiraj A. Vattem   Michael Givskov   Thomas Bovbjerg Rasmussen   Naomi Balaban     39
Quorum-Sensing Inhibitory Compounds   Dacheng Ren   Michael Givskov   Thomas Bovbjerg Rasmussen   Naomi Balaban     51
Mathematical Modeling of Quorum-Sensing Control in Biofilms   John Ward     79
Animal Models Commonly Used to Study Quorum-Sensing Inhibitors   Naomi Balaban   Michael Givskov   Thomas Bovbjerg Rasmussen   Andrea Giacometti   Oscar Cirioni     109
In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs   Naomi Balaban   Michael Givskov   Thomas Bovbjerg Rasmussen     119
Quorum Sensing in Streptococci   M. Dilani Senadheera   Fengxia Qi   Dennis Cvitkovitch     131
Ironing Out the Biofilm Problem: The Role of Iron in Biofilm Formation   E. Peter Greenberg   Ehud Banin     141
Clinical Wound Healing Using Signal Inhibitors   Randall D. Wolcott     157
Subject Index     171

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