Coronary Thrombolysis in Perspective: Principles Underlying Conjunctive and Adjunctive Therapy

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Editorial Reviews

Booknews
A critical review of the recent rapid advances in coronary thrombolysis, the most widely used initial treatment of acute myocardial infarction. Provides practical information for avoiding untoward effects and implementing both conjunctive and adjunctive measures, and highlights research on the relevant fundamental mechanisms. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

Table of Contents

Series Introduction
Preface
Contributors
1 Coronary Thrombolysis: Background and Factors Underlying Its Emergence 1
2 Thrombolytic Agents 11
3 The Nature of Atherosclerotic Lesions Giving Rise to Acute Coronary Thrombosis 35
4 The Objectives of Coronary Thrombolysis 53
5 The Impact of Time to Treatment on the Efficacy of Coronary Thrombolysis 65
6 Procoagulant Effects of Fibrinolytic Agents 77
7 The Role of Platelets in Thrombolysis, Thrombosis, and Thrombolytic Therapy 101
8 Relationships Between Suppression of Coagulation and Prevention of Reocclusion 123
9 Strengths and Limitations of Specific Antithrombotic Regimens and Agents 143
10 Discrepancies Between End-Point Results in Clinical Trials of Thrombolytic Therapy: The Salvage Paradigm Revisited 167
11 Coronary Artery Patency 183
12 Mortality as an End Point in Studies of Coronary Thrombolysis 193
13 Clinical Factors Militating Against Sustained Patency and Their Consequences 221
14 Efficacy of Currently Available Conjunctive Regimens 255
15 Myocardial Reperfusion Injury: Concepts, Mechanisms, and Therapeutic Strategies 271
Epilogue. Controversy and Clarification: Preliminary Results of the GUSTO Trial 303
Index 317
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