Cortical Development: Genes and Genetic Abnormalities / Edition 1

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To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.

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Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Modern neuroscience has clarified a good proportion of concepts regarding neuronal cell migration and development. This book reflects the current understanding in the field.
Purpose: The purpose is to address current gaps in the interaction between basic sciences and clinical conditions.
Audience: Neurologists, neuroscientists, and psychiatrists are the main audience. The authors are credible authorities in the field.
Features: In this well written book, experts in biological science as well as medical and neuroscience professionals discuss important concepts in new research and development. The many illustrations and fluid text allow readers to fully grasp the topic, regardless of their level of expertise. Although most of the book is devoted to the interaction between clinical neurological disorders and alterations in neuronal migration and maturation, the last two chapters discuss the association between neuronal migration and schizophrenia and alterations in neuronal migration in humans.
Assessment: This is an excellent book. It is well written, referenced, and illustrated.
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Product Details

  • ISBN-13: 9780470060926
  • Publisher: Wiley
  • Publication date: 3/21/2008
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 302
  • Product dimensions: 6.28 (w) x 9.27 (h) x 0.67 (d)

Table of Contents

Symposium on Cortical development: genes and genetic abnormalities,held at the Novartis Foundation, London, 6–8 February 2007.

Editors: Gregory Bock (Organizer) and Jamie Goode.

This symposium is based on a proposal made by ZoltánMolnár.

John G. Parnavelas Chair’s introduction.

Bradley J. Molyneaux, Paola Arlotta and Jeffrey D.Macklis/Molecular development of corticospinal motor neuroncircuitry.

Gordon Fishell /Perspectives on the developmental originsof cortical interneuron diversity. 

Pasko Rakic, Kazue Hashimoto-Torii and Matthew R.Sarkisian /Genetic determinants of neuronal migration in thecerebral cortex.

Stephen C. Noctor, Veronica Martinez-Cerdeño andArnold R. Kriegstein /Neural stem and progenitor cells incortical development.

Teresa H. Chae and Christopher A. Walsh /Genesthat control the size of the cerebral cortex.

Vicki Hammond, Joanne Britto, Eva So, Holly Cate andSeong-Seng Tan /Control of cortical neuron layering: lessonsfrom mouse chimeras.

Fujio Murakami, Daisuke Tanaka, Mitsutoshi Yanagida andEmi Yamazaki /Intracortical multidirectional migration ofcortical interneurons.

Libing Zhou, Fadel Tissir and André M.Goffinet /The atypical cadherin Celsr3 regulates thedevelopment of the axonal blueprint.

Dennis D. M. O’Leary , Shen-Ju Chou, TadashiHamasaki, Setsuko Sahara, Akihide Takeuchi, SandrineThuret and Axel Leingärtner /Regulation of laminarand area patterning of mammalian neocortex and behaviouralimplications.

Jeremy A. Cholfin and John L. R. Rubenstein/Genetic regulation of prefrontal cortex development andfunction.

Henry Kennedy, Rodney Douglas, Kenneth Knoblauch andColette Dehay /Self-organization and pattern formation inprimate cortical networks.

Nobuhiko Yamamoto, Takuro Maruyama, Naofumi Uesaka,Yasufumi Hayano, Makoto Takemoto and Akito Yamada/Molecular mechanisms of thalamocortical axon targeting.

Zoltán Molnár, Anna Hoerder-Suabedissen, Wei ZhiWang, Jamin DeProto, Kay Davies, Sheena Lee, Erin C.Jacobs, Anthony T. Campagnoni, Ole Paulsen, Maria CarmenPiñon and Amanda F. P. Cheung /Genes involved inthe formation of the earliest cortical circuits.

Michael Piper, Amber-Lee S. Dawson, Charlotta Lindwall, GuyBarry, Céline Plachez and Linda J. Richards/Emx and Nfi genes regulate cortical development andaxon guidance in the telencephalon.

Paul J. Harrison /Schizophrenia susceptibility genes andtheir neurodevelopmental implications: focus on neuregulin.

Peter B. Crino /Focal brain malformations: a spectrum ofdisorders along the mTOR cascade.

Index of contributors.

Subject Index.

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