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Doody's Review ServiceReviewer: Melanie M. Brandabur, MD (University of Illinois at Chicago College of Medicine)
Description: Corticobasal degeneration (CBD) is a rare and devastating neurodegenerative disorder presenting with clinical manifestations suggesting asymmetrical involvement of both basal ganglia and cortical structures and distinct pathological features. This book is an overview of this disease including chapters from a variety of experts on epidemiology, pathology, diagnosis, radiology, and other aspects of this condition.
Purpose: The editors have assembled this volume to clarify issues of diagnosis and pathology of CBD in order to enable clinicians to reach an earlier diagnosis. An additional purpose is to outline areas of future research in this area. Both objectives are worthwhile and are definitely met by the editors.
Audience: The book is directed at clinical and basic science researchers especially within the fields of movement disorders, neurology, and neuroepidemiology. The editors and the majority of the contributors are acknowledged experts within their fields.
Features: Each feature of the clinical presentation of CBD is discussed in detail, including "alien hand sign," dystonia, eye movement abnormalities, and neuropsychological presentation. In addition to issues of diagnosis, clinical presentation, pathology, radiology ,and therapy of the editors discuss "look-alikes" such as unilateral limb dystonia that may contribute to confusion in diagnosis of CBD.
Assessment: This is a very useful compilation in which many issues pertaining to appropriate recognition and future understanding of this devastating and incompletely understood condition are clarified.