Corticobasal Degeneration / Edition 1

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Editorial Reviews

Doody's Review Service
Reviewer: Melanie M. Brandabur, MD (University of Illinois at Chicago College of Medicine)
Description: Corticobasal degeneration (CBD) is a rare and devastating neurodegenerative disorder presenting with clinical manifestations suggesting asymmetrical involvement of both basal ganglia and cortical structures and distinct pathological features. This book is an overview of this disease including chapters from a variety of experts on epidemiology, pathology, diagnosis, radiology, and other aspects of this condition.
Purpose: The editors have assembled this volume to clarify issues of diagnosis and pathology of CBD in order to enable clinicians to reach an earlier diagnosis. An additional purpose is to outline areas of future research in this area. Both objectives are worthwhile and are definitely met by the editors.
Audience: The book is directed at clinical and basic science researchers especially within the fields of movement disorders, neurology, and neuroepidemiology. The editors and the majority of the contributors are acknowledged experts within their fields.
Features: Each feature of the clinical presentation of CBD is discussed in detail, including "alien hand sign," dystonia, eye movement abnormalities, and neuropsychological presentation. In addition to issues of diagnosis, clinical presentation, pathology, radiology ,and therapy of the editors discuss "look-alikes" such as unilateral limb dystonia that may contribute to confusion in diagnosis of CBD.
Assessment: This is a very useful compilation in which many issues pertaining to appropriate recognition and future understanding of this devastating and incompletely understood condition are clarified.
Melanie M. Brandabur
Corticobasal degeneration (CBD) is a rare and devastating neurodegenerative disorder presenting with clinical manifestations suggesting asymmetrical involvement of both basal ganglia and cortical structures and distinct pathological features. This book is an overview of this disease including chapters from a variety of experts on epidemiology, pathology, diagnosis, radiology, and other aspects of this condition. The editors have assembled this volume to clarify issues of diagnosis and pathology of CBD in order to enable clinicians to reach an earlier diagnosis. An additional purpose is to outline areas of future research in this area. Both objectives are worthwhile and are definitely met by the editors. The book is directed at clinical and basic science researchers especially within the fields of movement disorders, neurology, and neuroepidemiology. The editors and the majority of the contributors are acknowledged experts within their fields. Each feature of the clinical presentation of CBD is discussed in detail, including ""alien hand sign,"" dystonia, eye movement abnormalities, and neuropsychological presentation. In addition to issues of diagnosis, clinical presentation, pathology, radiology ,and therapy of the editors discuss ""look-alikes"" such as unilateral limb dystonia that may contribute to confusion in diagnosis of CBD. This is a very useful compilation in which many issues pertaining to appropriate recognition and future understanding of this devastating and incompletely understood condition are clarified.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780781721240
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 2/1/2000
  • Series: Advances in Neurology Ser.
  • Edition number: 1
  • Pages: 255
  • Product dimensions: 7.16 (w) x 10.12 (h) x 0.87 (d)

Table of Contents

Contributing Authors
Foreword
Preface
I Diagnostic and Epidemiologic Issues
1 Nineteenth Century Studies of Atypical Parkinsonism: Charcot and His Salpetriere School 1
2 Neuropathologic and Molecular Considerations 9
3 Clinical Diagnostic Criteria 29
4 Focal and Asymmetric Cortical Degenerative Syndromes 35
5 Epidemiologic Aspects 53
II Clinical Features
6 Dystonia in Corticobasal Degeneration 61
7 Myoclonus in Corticobasal Degeneration and Other Neurodegenerations 69
8 Parkinsonism in Corticobasal Degeneration 83
9 Memory and Executive Processes in Corticobasal Degeneration 91
10 Apraxia in Corticobasal Degeneration 103
11 Aphasia in Corticobasal Degeneration 123
12 Alien Limb Sign 135
13 Neuropsychiatric Aspects of Corticobasal Degeneration 147
14 Speech and Swallowing Disturbances in Corticobasal Degeneration 153
15 Eye Movement Disorders in Corticobasal Degeneration 161
III Diagnosis and Prognosis
16 Corticobasal Degeneration Look-alikes 169
17 Phenotypes and Prognosis: Clinicopathologic Studies of Corticobasal Degeneration 183
IV Neuroradiology and Management
18 Magnetic Resonance Imaging in CBD, Related Atypical Parkinsonian Disorders, and Dementias 197
19 Functional Imaging Studies in Corticobasal Degeneration 209
20 Therapeutic Approaches 217
V Diagnostic Controversies and Conclusions
21 Diagnostic Controversies: Is CBD Part of the "Pick Complex"? 223
22 Diagnostic Controversies: Another View 233
23 Conclusions 241
Subject Index 245
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