Creatine Kinase and Brain Energy Metabolism: Function and Disease

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Material from a recent workshop summarizes the existing knowledge on energy metabolism and the creatine kinase (CK) system in healthy and diseased brains and defines new directions for research. Chapters review fundamentals of brain energy metabolism and the CK systems and examine the effects of CK deficiency in muscle. The cellular and molecular biological aspects of the CK system are described in brain, heart, and skeletal muscle, and creatine transport and cellular neuroprotection are reviewed. Final sections of the book describe the CK system and brain energy metabolism in neurological diseases and disease models. There is no subject index. Annotation ©2004 Book News, Inc., Portland, OR
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Table of Contents

What Do We Know of Cellular Bioenergetics: Basic Pattern of its Organization and the Role of Creatine Kinase System 3
The Creatine Kinase Catalyzed Reaction in the Developing Brain 25
Morphological and Physiological Consequences of CK Deficiency in Muscle Cells of CK-/- Mice 39
Smoothing Energy Fluctuations in the Cell: The Role of Compartmentation 55
Mathematical Modeling of Regulation of Oxidative Phosphorylation in Cardiomyocytes 59
Muscle-Type Creatine Kinase Binds to a Sarcoplasmic Reticulum 130-170 kD Polypeptide Triplet on Overlay Blots 75
Tissue Specific Binding of a Brain Protein to the Conserved 3' Untranslated Region of Ubiquitous Mitochondrial Creatine Kinase mRNA 85
Regulation of Rat Creatine Transporter by Creatine Availability 97
Creatine Prevents the Cytotoxicity of Haloperidol by Alteration of NO/Ras/NF-[kappa]B System 113
Comparative Study of Creatine Kinase-BB Decrease in the Brains of Patients with Alzheimer's Disease and Schizophrenia 125
Guanidinoacetate Methyltransferase (GAMT) Deficiency: Clinical Features, Biochemical and Genetic Aspects, Diagnosis and Treatment 133
GAMT vs. AGAT Brain Creatine Depletions: Clinical, Biochemical, Brain Magnetic Resonance Imaging and Proton Spectroscopy Features 135
NMR Studies of Brain Energy Metabolism and Excitotoxicity: Advantages and Advances 147
On the Participation of GAB, K[superscript +], ACH and NH[subscript 3] in the Formation of Energetically Indivisible Neuron-Neuroglial System 163
The Role of Oxygen and Nitrogen Reactive Species in Pathogenesis of Ischemic Stroke 171
The Role of the Changes in the State of Brain for Regulation of some Lipid and Carbohydrate Metabolic Processes 183
Author Index 191
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