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From The CriticsReviewer: Howard H. Sky-Peck, MD, PhD, FRSM (Rush Medical College of Rush University)
Description: This is an excellent up-to-date review of x-ray crystallography to solve the three-dimensional structures of proteins, nucleic acids, and their complexes.
Purpose: The aim of a crystal structure determination is to provide information that will solve biologically relevant problems; that process normally requires a high resolution of structure. The preparation of suitable crystals for high resolution remains a major bottleneck in structural determinations. This book describes in detail the production of crystalline derivatives and the data collection required for high resolution structures needed for analysis. X-ray crystallography is a well-defined physical technique, and it is possible to reconstruct the x-ray diffraction pattern from the electron density map generated by solving the three-dimensional structure.
Audience: The book is intended for biochemists, biophysicists, and teachers and graduate students of biological sciences.
Features: The editors present chapters written by various individuals who are experts in the field of x-ray crystallography. The first part of the book describes the theory, mathematics, and interpretations of various patterns created by x-ray. The later portion of the book describes the application of x-ray crystallography to a series of specialized topics that are among the most interesting areas of structural biology.
Assessment: I highly recommends this book for scientifically oriented libraries, laboratories, and students specializing in macromolecules, their shape and function.