CURED I - LENT Late Effects of Cancer Treatment on Normal Tissues / Edition 1

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Overview

This volume is based on the LENT V NCI-sponsored meeting held in May 2004 and the CURED I Conference in 2006. Written by experts in the field, it addresses a critical topics relating to late effects, such as mechanisms of injury, the role of screening, options for interventions, second malignancies, and prevention. It is hoped that these findings will help readers to prevent and treat the long-term side-effects of irradiation.

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Editorial Reviews

Doody's Review Service
Reviewer: Ann Pittier, MD (University of Washington Medical Center)
Description: With the tremendous success of cancer management, the goal of treatment has been to improve the therapeutic ratio in order to preserve an acceptable quality of life for patients who survive cancer. Treatments offered to preserve life are increasingly effective, but leave patients with life-long sequelae. This book provides those in the research and clinical setting a fundamental foundation upon which to build.
Purpose: The focus is on providing a molecular and physiologic understanding of the long-term side effects that often plague cancer survivors. This is particularly imperative as more patients are cured with modern medicine and radiation. To provide optimal care for these patients, a long term "chronic disease approach" must be employed, and researchers and clinicians alike must have a firm basis of understanding of the processes behind the side effects. Even with improvement of the therapeutic ratio this remains an important aspect of patient care and must be addressed in a multidisciplinary setting. This book provides a basic science understanding of the processes behind the side effects of radiation.
Audience: This book is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. It provides the framework for the knowledge that can be gained via scientific application or in a clinical setting.
Features: The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. Each chapter begins with a summary and is divided into clearly labeled segments. Chapters outline the guidelines and models for researchers and clinicians to use and address the in-depth physiologic and molecular background of radiation sequelae. This book is not meant to be a definitive text on diagnosis and management, but rather a platform upon which to build clinical/research knowledge.
Assessment: This fundamental look at long-term side effects of radiation should be in the library of every radiation oncology department. It details the current scientific understanding of the basis of side effects that are becoming increasingly important as more and more cancers are either cured or transitioned into "chronic disease" status.
From the Publisher

From the reviews:

"This book provides a basic science understanding of the processes behind the side effects of radiation. … is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. … The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. … Chapters outline the guidelines and models for researchers and clinicians … . should be in the library of every radiation oncology department." (Ann Pittier, Doody’s Review Service, August, 2008)

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Product Details

  • ISBN-13: 9783540490692
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 10/28/2007
  • Series: Medical Radiology / Radiation Oncology Series
  • Edition description: 2008
  • Edition number: 1
  • Pages: 140
  • Product dimensions: 7.60 (w) x 10.70 (h) x 0.50 (d)

Table of Contents

Radiation (and Medical) Biosurveillance: Screening Survivors for Late Effects of Therapy.- Radiation Biodefense: Medical Countermeasures to Radiation Injury: Science and Service in the Public Interest. A Tribute to Robert Kallman.- Radiation Biopathology: Ionizing Radiation and the Endothelium.- Radiation Biomarkers: Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.- Radiation Biomechanisms: Volume Effects in Radiation Damage to Rat Lung.- Radiation Bioimaging: The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury.- Radiation Biophysiology: Screening for Cardiovascular Disease in Survivors of Thoracic Radiation.- Radiation Biointervention: Hypoxia Mediated Chronic Normal Tissue Injury: A New Paradigm and Potential. Strategies for Intervention.- Radiation Bioprevention: Prevention and Treatment of Radiation Injuries: The Role of the Renin-Angiotensin System.- Radiation Bioepidemiology: Second Malignancies as a Consequence of Radiation Therapy.- Radiation Bioinformatics: Using Quality of Life Information to Rationally Incorporate Normal Tissue Effects into Treatment Plan Evaluation and Scoring.- Radiation Bioscoring: Cancer-Related Fatigue as a Late Effect: Severity in Relation to Diagnosis, Therapy, and Related Symptoms.- Radiation Biotoxicity Taxonomy: A Normal Tissue TNM Toxicity Taxonomy: Scoring the Adverse Effects of Cancer Treatment.- Radiation Biocontinuum: Follow-Up Care For Cancer Survivors: Needs, Issues, and Strategies.
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