Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science [NOOK Book]

Overview

“Nathalia Holt presents a thorough account of the research that provides scientists with hope that a cure will one day be achievable... and her empathy shines through in her prose. This is as important a social history as it is a medical document.”—The Daily Beast
 
Two patients—each known in medical history as the Berlin Patient—were cured of the HIV virus. The two patients’ disparate cures came twelve years apart, but Nathalia Holt, an award-winning scientist at the forefront of HIV research, connects the ...
See more details below
Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

Available on NOOK devices and apps  
  • NOOK Devices
  • Samsung Galaxy Tab 4 NOOK 7.0
  • Samsung Galaxy Tab 4 NOOK 10.1
  • NOOK HD Tablet
  • NOOK HD+ Tablet
  • NOOK eReaders
  • NOOK Color
  • NOOK Tablet
  • Tablet/Phone
  • NOOK for Windows 8 Tablet
  • NOOK for iOS
  • NOOK for Android
  • NOOK Kids for iPad
  • PC/Mac
  • NOOK for Windows 8
  • NOOK for PC
  • NOOK for Mac
  • NOOK for Web

Want a NOOK? Explore Now

NOOK Book (eBook)
$11.99
BN.com price

Overview

“Nathalia Holt presents a thorough account of the research that provides scientists with hope that a cure will one day be achievable... and her empathy shines through in her prose. This is as important a social history as it is a medical document.”—The Daily Beast
 
Two patients—each known in medical history as the Berlin Patient—were cured of the HIV virus. The two patients’ disparate cures came twelve years apart, but Nathalia Holt, an award-winning scientist at the forefront of HIV research, connects the molecular dots of these cases for the first time.
 
Scientists are known to maintain a professional distance from those they study, but sometimes scientists are not just investigators, they are caregivers, too. Cured illustrates that even in the era of high-tech and big pharma, the way doctors and patients communicate remains a critical ingredient in the advance of this science. Holt offers a kind of hope that the thirty-four million people currently infected with HIV need and a story of ingenuity, dedication, and humanity that will inspire the rest of us.
Read More Show Less

Editorial Reviews

Publishers Weekly
11/04/2013
HIV researcher Holt relates how two HIV-positive men together upended the treatment for the virus that causes AIDS, and helped save countless lives. The two “Berlin patients,” as they became anonymously known in medical literature—German-born Christian Hahn and American Timothy Brown—never knew each other. But in this accessible and fascinating account, Holt, a research scientist trained at MIT and Harvard, juggles genetic mysteries, research perils, the agonies of these two reserved and sensitive men diagnosed with what was considered a death sentence, and the dogged doctors who successfully treated them during the later stages of AIDS epidemic—Hahn, in 1996, with early drug therapy and an experimental cancer drug, and Brown, in 2008, with a stem-cell transplant. Holt’s narrative brings to light the remarkable early breakthroughs in treating a once fatal condition, but for the Berlin patients, “it wasn’t a cure that anyone would want.” By themselves, Holt notes, “the Berlin patient cases were anomalies... invitations to fulfill... the promise that HIV can be cured.” Their stories, however, are not just memorable for HIV patients, doctors and scientists, but for a society that believes in the importance of their struggles and hopes for their success. Agent: Laurie Abkemeier, DeFiore and Company. (Mar.)
From the Publisher
Praise for Cured

"In this accessible and fascinating account, Holt, a research scientist trained at MIT and Harvard...brings to light the remarkable early breakthroughs in treating a once fatal condition." - Publishers Weekly

"A fascinating discourse on how medical science is zeroing in on an HIV vaccine after several anomalous triumphs...An astute AIDS retrospective blended with contemporary updates on aggressive medical strategies." - Kirkus Reviews

“In this exquisitely detailed telling of medicine's desperate fight to control the HIV epidemic, author Nathalia Holt reminds us that all the best medical stories are foremost stories of people - their determination, their courage, and their ability, in the best of circumstances, to rewrite history in a way that protects us all.”—Deborah Blum, author of The Poisoner's Handbook

“I am eagerly anticipating Nathalia Holt’s telling of the Berlin Patients and the implications of their apparent cure from HIV infection.”
—David Baltimore, Nobel Laureate for Medicine, professor of Biology, and former president, California Institute of Technology

Library Journal
09/15/2013
In a book bound to stir hope, interest, and debate, Holt, a research scientist specializing in HIV biology, discusses the science behind what appears to be a functional cure of HIV. At its heart: two men known as the Berlin Patients successfully treated in the German capital in 1996 and in 2002.
Kirkus Reviews
2014-01-09
A fascinating discourse on how medical science is zeroing in on an HIV vaccine after several anomalous triumphs. With the AIDS epidemic now in its fourth decade, award-winning HIV research scientist Holt believes "we are only just beginning to understand our shared evolution with viruses." Still, she offers increasing hope for a cure by spotlighting the two male "Berlin Patients" and several others, including a child, who chemically bombarded and expunged the HIV virus from their bodies. The author tracks the enduring histories of these men—German-born Christian Hahn and Timothy Brown, an American—from the detection of their initial viral prodromes to the astonishing depletion of HIV-infected cells from their bodies, prompting clinical trials and controversial research. Holt also profiles HIV specialists Heiko Jessen, Bruce Walker and David Ho as part of a frustrated yet galvanized group of professionals working toward developing new therapies to either counterbalance HIV's onslaught on a vulnerable immune system or, ideally, discover a way to have the virus coexist with its human host. The author includes research that field experts consider "pertinent and exciting," and the result makes for educative, thought-provoking and frequently alarming reading. Textbook descriptions on the intricacies of HIV's tactical viral transmission commingle with a timeline spanning from an era when a seropositive test result equaled a sure death sentence. The author also examines controversial trials of AZT drug therapies, stem cell transplants, and the genetic suppression and inexplicable eradication of the virus from a fortunate few. Holt further supports her subject with graphic illustrations and a well-balanced assortment of interviews and opinions from doctors, genetic scientists and informed researchers, all unified in the global battle to find a cure. An astute AIDS retrospective blended with contemporary updates on aggressive medical strategies.
Read More Show Less

Product Details

  • ISBN-13: 9780698148543
  • Publisher: Penguin Publishing Group
  • Publication date: 2/27/2014
  • Sold by: Penguin Group
  • Format: eBook
  • Pages: 336
  • File size: 2 MB

Meet the Author


Nathalia Holt is an award-winning research scientist specializing in HIV biology. Her research has led to major developments in the HIV gene therapy field.  She has trained at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, the University of Southern California and Tulane University. She lives with her husband and their daughter in Boston, Massachusetts.
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)