Cystic Fibrosis in the 21st Century / Edition 1

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Overview

This volume is the first overview of the entire field of cystic fibrosis and reflects new understandings about the disease and its pathophysiology. The text encompasses basic molecular and cellular biology as well as the recent multisystem, multidisciplinary advances in the clinical care of patients. As a result of the emphasis on new developments, most of the references are less than five years old. The wide range of topics covered include the CFTR gene; research in pseudomonas aeruginosa; advanced disease management; advances in transplant medicine; and diabetes in cystic fibrosis. A concluding paper addresses future trends and possible problems in diagnosis, management, research and treatment. Annotation © 2006 Book News, Inc., Portland, OR
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Product Details

  • ISBN-13: 9783805579605
  • Publisher: Karger, S. Inc.
  • Publication date: 1/28/2006
  • Series: Progress in Respiratory Research Series
  • Edition number: 1
  • Pages: 330
  • Product dimensions: 8.40 (w) x 11.20 (h) x 0.70 (d)

Table of Contents

Ch. 1 The CFTR gene : structure, mutations and specific therapeutic approaches 2
Ch. 2 Exquisite and multilevel regulation of CFTR expression 11
Ch. 3 Intracellular processing of CFTR 21
Ch. 4 Structure of the cystic fibrosis transmembrane conductance regulator 29
Ch. 5 Function of CFTR protein : ion transport 38
Ch. 6 Cystic fibrosis : function of CFTR protein : regulatory functions 45
Ch. 7 Function of CFTR protein : developmental role 54
Ch. 8 Genotype-phenotype correlations in cystic fibrosis 61
Ch. 9 Diagnosis of cystic fibrosis, CFTR-related disease and screening 69
Ch. 10 CF modifier genes 77
Ch. 11 Animal models 84
Ch. 12 In vitro/ex vivo fluorescence assays of CFTR chloride channel function 93
Ch. 13 In vivo measurement of airway potential difference to assess CFTR function in man 102
Ch. 14 Arrays and proteomics 109
Ch. 15 Pathogenesis of pulmonary disease in cystic fibrosis 116
Ch. 16 Infection versus inflammation 122
Ch. 17 Pseudomonas aeruginosa : clinical research 131
Ch. 18 Pseudomonas aeruginosa : basic research 138
Ch. 19 Other gram-negative organisms : Burkholderia cepacia complex and Stenotrophomonas maltophilia 145
Ch. 20 Staphylococcus aureus and MRSA 153
Ch. 21 Nontuberculous mycobacterial lung disease in patients with cystic fibrosis 160
Ch. 22 Respiratory fungal infections and allergic bronchopulmonary aspergillosis 166
Ch. 23 Advanced disease management and advances in transplant medicine 173
Ch. 24 Current and novel antimicrobial approaches 180
Ch. 25 Anti-inflammatory agents : a clinical perspective 187
Ch. 26 Recent advances in infant and pre-school lung function 195
Ch. 27 Recent advances in imaging 205
Ch. 28 New pharmacological approaches for treatment of cystic fibrosis 212
Ch. 29 Gene and stem cell therapy 221
Ch. 30 Gut disease : clinical manifestations, pathophysiology, current and new treatments 232
Ch. 31 Pancreatic involvement : clinical manifestations, pathophysiology and new treatments 242
Ch. 32 Cystic fibrosis : liver disease 251
Ch. 33 Fertility, contraception, incontinence and pregnancy 264
Ch. 34 Arthritis, vasculitis and bone disease 270
Ch. 35 Diabetes in cystic fibrosis 278
Ch. 36 Challenges for nurses 286
Ch. 37 Dietetics 293
Ch. 38 Physiotherapy 301
Ch. 39 Psychological interventions 309
Ch. 40 The future 316
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