Cytokine Knockouts / Edition 2

by Giamila Fantuzzi

Overview

Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Product Details

ISBN-13:	9781588291943
Publisher:	Springer-Verlag New York, LLC
Publication date:	07/30/2003
Series:	Contemporary Immunology
Edition description:	2nd ed. 2003
Pages:	471
Product dimensions:	7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

I. Cytokine Knockouts in Models of Human Disease.- 1. Cytokine Knockouts in Inflammation.- 2. The Use of Cytokine Knockouts to Study Host Defense Against Infection.- 3. The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease.- 4. The Use of Cytokine Knockout Mice in Cancer Research.- 5. The Use of Cytokine Knockout Mice in Neuroimmunology.- II. Cytokine Knockout Mice.- 6. The Role of IL-1 in the Immune System.- 7. IL-1 Receptor Antagonist-Deficient Mice.- 8. A Unique Role for IL-2 in Self-Tolerance.- 9. Molecular Basis for Binding Multiple Cytokines by—c: Implications for X-SCID and Impaired—c-Dependent Cytokine Receptor Function.- 10. G-CSF, GM-CSF, and IL-3 Knockout Mice.- 11. IL-4 Knockout Mice.- 12. Role of IL-5 in Immune and Pathological Responses in the Mouse.- 13. IL-6 Knockout Mice.- 14. IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation.- 15. IL-12-Deficient Mice.- 16. IL-13 and Double IL-4/IL-13 Knockout Mice.- 17. IL-15: Insights from Characterizing IL-15-Deficient Mice.- 18. IL-18 and IL-18 Receptor Knockout Mice.- 19. Mice Knockouts for Chemokines and Chemokine Receptors.- 20. IFN-γ and IFN-γ Receptor Knockout Mice.- 21. Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice.- 22. Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice.- 23. RANKL, RANK, and OPG.- 24. Targeting the TGF-β Pathway In Vivo: Defining Complex Roles for TGF-β Signaling in Immune Function, Wound Healing, and Carcinogenesis.- 25. Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models.

Editorial Reviews

Foreword by Scott K. Durum

Reviews of the first edition:

...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne

". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal

"...essential reading for...laboratory scientists, including immunologists, developmental and cell biologists, and experimental pathologists..."

-Modern Pathology

"...a very nice compendium of research in a very important area...should be on the shelves of all life science/biomedical libraries."

-Doody's Health Sciences Book Review Journal

"This remarkable book is a powerful source of information and ideas."

-Annales de Biologie Clinique

From the Publisher