Cytokines and Chemokines in Autoimmune Disease

Overview

This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention. The outstanding features of this book are that it is divided in chapters each focusing on specific, highly prevalent autoimmune disorders. The role of cytokines and chemokines in each of these disorders is dissected in the context of the autoinimune responses that drive these diseases. ...

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Paperback (Softcover reprint of the original 1st ed. 2003)
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Overview

This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention. The outstanding features of this book are that it is divided in chapters each focusing on specific, highly prevalent autoimmune disorders. The role of cytokines and chemokines in each of these disorders is dissected in the context of the autoinimune responses that drive these diseases. Importantly, each chapter is meant to provide an in-depth review of how cytokines and chemokines participate in each disease, rather than very specific aspects of cytokine or chemokine biology. The book therefore provides an integrated view of how multiple cytokines and chemokines participate in the initiation and evolution of both systemic and organ-specific pathological immune responses.

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Product Details

  • ISBN-13: 9781461349525
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series , #520
  • Edition description: Softcover reprint of the original 1st ed. 2003
  • Edition number: 1
  • Pages: 295
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.65 (d)

Table of Contents

Preface
1 Cytokines and Chemokines in Autoimmune Disease: An Overview 1
2 Cytokines and Chemokines - Their Receptors and Their Genes: An Overview 8
3 Cytokine and Cytokine Receptor Genes in the Susceptibility and Resistance to Organ-Specific Autoimmune Diseases 33
4 Cytokines, Lymphocyte Homeostasis and Self Tolerance 66
5 The Role of Cytokines as Effectors of Tissue Destruction in Autoimmunity 73
6 Cytokines in the Treatment and Prevention of Autoimmune Responses - A Role of IL-15 87
7 Cytokines in the Pathogenesis and Therapy of Autoimmune Encephalomyelitis and Multiple Sclerosis 96
8 Chemokines in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis 120
9 Cytokines and Chemokines in the Pathogenesis of Murine Type 1 Diabetes 133
10 Immunoregulation by Cytokines in Autoimmune Diabetes 159
11 Cytokines in the Pathogenesis of Rheumatoid Arthritis and Collagen-Induced Arthritis 194
12 Cytokines and Chemokines in Virus-Induced Autoimmunity 203
13 Cytokines and Chemokines in Human Autoimmune Skin Disorders 221
14 Involvement of Cytokines in the Pathogenesis of Systemic Lupus Erythematosus 237
15 Cytokines, Chemokines and Growth Factors in the Pathogenesis and Treatment of Inflammatory Bowel Disease 252
Index 287
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