Cytokines and the CNS / Edition 1

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Overview

As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines and their relationship with the central nervous system.

Cytokines and the CNS, Second Edition, designed for both clinicians and researchers, offers a fresh perspective and deepened insight into how cytokine action impacts the physiology and pathology of the nervous system. The similarity between factors involved in inflammation or immunity and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist's cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated on by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Alexander Kolchinsky, PhD (University of Illinois at Chicago College of Medicine)
Description: This book consists of 14 chapters divided into three areas. The first four chapters give the necessary general background on cytokines, signaling pathways they initiate, cellular responses to cytokines, and cellular composition of brain tissue. The next four chapters elaborate the effects of cytokines on different components of brain tissue. The last six chapters translate this basic knowledge into the problems of individual pathophysiological conditions, namely infections, multiple sclerosis, Alzheimer disease and other dementia, malignancies, AIDS, and trauma.
Purpose: The purpose was is to summarize a vast body of data generated by several different disciplines and to present it to specialists of diverse backgrounds. The need for such a review was dictated by the rapid growth of molecular studies of cytokines and their receptors, availability of these molecules in substantial amounts for experimentation, and their use for clinical treatments.
Audience: The book is intended for a broad audience of students, trainees, and specialists involved in neuroscience. Due to the extensive background in the first chapters, the book is in a sense self-sufficient, and does not require preliminary reading beyond basic physiology and molecular biology.
Features: The book is illustrated by well-organized black-and-white schemes and relevant and informative microphotographs. Half-tone illustrations are rather poorly reproduced. The structure of the book is outlined in the preface but not reflected in the table of contents. The book has a well-compiled index, but is wanting for a list of abbreviations and a glossary.
Assessment: This is a timely, well-written, and carefully edited book. It demonstrates that the majority of signaling molecules discovered in diverse cellular systems are consistently found to play important roles in the control of the most complex tissue, the brain.
Alexander Kolchinsky
This book consists of 14 chapters divided into three areas. The first four chapters give the necessary general background on cytokines, signaling pathways they initiate, cellular responses to cytokines, and cellular composition of brain tissue. The next four chapters elaborate the effects of cytokines on different components of brain tissue. The last six chapters translate this basic knowledge into the problems of individual pathophysiological conditions, namely infections, multiple sclerosis, Alzheimer disease and other dementia, malignancies, AIDS, and trauma. The purpose was is to summarize a vast body of data generated by several different disciplines and to present it to specialists of diverse backgrounds. The need for such a review was dictated by the rapid growth of molecular studies of cytokines and their receptors, availability of these molecules in substantial amounts for experimentation, and their use for clinical treatments. The book is intended for a broad audience of students, trainees, and specialists involved in neuroscience. Due to the extensive background in the first chapters, the book is in a sense self-sufficient, and does not require preliminary reading beyond basic physiology and molecular biology. The book is illustrated by well-organized black-and-white schemes and relevant and informative microphotographs. Half-tone illustrations are rather poorly reproduced. The structure of the book is outlined in the preface but not reflected in the table of contents. The book has a well-compiled index, but is wanting for a list of abbreviations and a glossary. This is a timely, well-written, and carefully edited book. It demonstrates that the majority of signalingmolecules discovered in diverse cellular systems are consistently found to play important roles in the control of the most complex tissue, the brain.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780849324529
  • Publisher: CRC Press
  • Publication date: 1/28/1996
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 368
  • Product dimensions: 6.47 (w) x 9.55 (h) x 0.88 (d)

Table of Contents

Ch. 1 The CNS : cells, tissues, and reactions to insult 1
Ch. 2 Cytokines : wherefrom and whereto 23
Ch. 3 Cytokine receptors 39
Ch. 4 Cytokines and signaling 53
Ch. 5 Inflammatory complexities in the CNS : new insights into the effects of intracellular redox state and viral infection in modulating the biology of oligodendrocytes and their precursor cells 67
Ch. 6 Cytokines and development of the nervous system 93
Ch. 7 Cytokines in CNS inflammation 113
Ch. 8 Cytokines and immune regulation in the nervous system 137
Ch. 9 Cytokines and neurodegeneration 163
Ch. 10 Cytokine expression and signaling in brain tumors 193
Ch. 11 Cytokines and defense and pathology of the CNS 243
Ch. 12 Cytokines and multiple sclerosis 269
Ch. 13 Cytokines in brain trauma and spinal cord injury 299
Ch. 14 Cytokine-based therapeutics for intrinsic CNS disease processes 327
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