Cytokines

Overview

Our most complete understanding of hormone receptor signaling may be exemplified in a family of hormones and receptors known as the cytokine superfamily. This volume is devoted to describing members of this hormone/receptor family from their molecular structures to their physiological effects. These hormones are not only biologically fascinating, but are also tremendously useful medicines.
The first three chapters review the basic events in binding and signaling. The remaining ...

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Overview

Our most complete understanding of hormone receptor signaling may be exemplified in a family of hormones and receptors known as the cytokine superfamily. This volume is devoted to describing members of this hormone/receptor family from their molecular structures to their physiological effects. These hormones are not only biologically fascinating, but are also tremendously useful medicines.
The first three chapters review the basic events in binding and signaling. The remaining papers present the cellular biology and physiological processes controlled by these hormones and receptors.

Audience: Biochemists, molecular biologists, cell biologists, immunologists, endocrinologists, and biomedical researchers.

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Editorial Reviews

From the Publisher
Praise for the Series
"The authority, originality, and editing of the reviews are first class."
—NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
—JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Doody's Review Service
Reviewer: Alvin Telser, PhD (Northwestern University Feinberg School of Medicine)
Description: This is a very thorough and timely presentation of the protein chemistry and biology of four-helix cytokines. It is Volume 52 in the series Advances in Protein Chemistry.
Purpose: The editor describes this volume as a presentation and discussion of cytokines from a molecular and structural perspective to their cellular and physiological roles. These molecules are widely distributed in many phyla, and their actions are physiologically very important. Therefore, these objectives are worthwhile and are very well attained.
Audience: This volume is intended for knowledgeable researchers as well as for individuals who wish to become informed about this field. This in an appropriate audience. The contributors of the six chapters are well known experts in each of the fields discussed.
Features: In the first three chapters the common structural features of these molecules and the signaling mechanisms they employ are presented. The last three chapter contributors discuss many cellular, physiological, and roles of cytokines. The book has no special features and no significant shortcomings.
Assessment: This book will be of interest and value to anyone wishing to learn and understand about structure-function relationships of this large class of cytokines. It is a very good book and should be in the collection of any life science library.
Gene A. Homandberg
This Advances in Protein Chemistry volume on linkage thermodynamics of macromolecular interactions introduces and updates topics dealing with the role of electrostatic contributions to free energies of soluble molecules, analysis of mutational effects on protein interactions, allosteric transitions of acetylcholine receptor, hemoglobin allostery, statistical thermodynamic linkage between conformations and binding equilibria, effects of salts and solutes on protein and nucleic acid equilibria, and effect of cosolvents on protein stability and reactions. It is meant to present selected topics on the role of linkage thermodynamics in explaining protein folding, protein stability, allostery, and protein-ligand interaction. The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions. The material is aimed at the specialist, but an introduction or overview for the less initiated would have been helpful. Nonetheless, any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative. This attractive volume is of the quality of all of the books in the series and has the typical high quality text, figures, and subject index. This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics. With such a detailed overview of these specific concepts, there is something in these chapters for everyone.
Alvin Telser
This is a very thorough and timely presentation of the protein chemistry and biology of four-helix cytokines. It is Volume 52 in the series Advances in Protein Chemistry. The editor describes this volume as a presentation and discussion of cytokines from a molecular and structural perspective to their cellular and physiological roles. These molecules are widely distributed in many phyla, and their actions are physiologically very important. Therefore, these objectives are worthwhile and are very well attained. This volume is intended for knowledgeable researchers as well as for individuals who wish to become informed about this field. This in an appropriate audience. The contributors of the six chapters are well known experts in each of the fields discussed. In the first three chapters the common structural features of these molecules and the signaling mechanisms they employ are presented. The last three chapter contributors discuss many cellular, physiological, and roles of cytokines. The book has no special features and no significant shortcomings. This book will be of interest and value to anyone wishing to learn and understand about structure-function relationships of this large class of cytokines. It is a very good book and should be in the collection of any life science library.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780120342525
  • Publisher: Elsevier Science
  • Publication date: 10/5/1998
  • Edition number: 1
  • Pages: 310

Meet the Author

Dr. James B. Wells is a professor in the Department of Criminal Justice in the College of Justice & Safety at Eastern Kentucky University. Earlier in his career, he was a correctional officer at the Southern Ohio Correctional Facility in Lucasville, Ohio, and later, a criminal justice planner for an architectural and engineering firm that specialized in designing correctional and other justice-related facilities.

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Table of Contents

N.A. Nicola and D.J. Hilton, General Classes and Functions of Four-Helix Bundle Cytokines.
A.A. Kossiakoff and A.M. de Vos, Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation.
L. Rocco Carpenter, G.D. Yancopoulos, and N. Stahl, General Mechanisms for Cytokine Receptor Signaling.
M. Socolovsky, S.N. Constantinescu, S. Bergelson, A. Sirotkin, and H.F. Lodish, Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function.
C.M. Silva, J. Isgaard, and M.O. Thorner, Cytokines in Endocrine Function.
M.F. Mehler and J.A. Kessler, Cytokines in Brain Development and Function.
Subject Index.
Author Index.

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