Death Receptors in Cancer Therapy / Edition 1

Death Receptors in Cancer Therapy / Edition 1

by Wafik S. El-Deiry
     
 

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ISBN-10: 1588291723

ISBN-13: 9781588291721

Pub. Date: 12/14/2009

Publisher: Springer-Verlag New York, LLC

Through use of this text, the reader is educated about the death ligands, death receptor pathways and their alterations in human cancer. The reader will learn about novel emerging signal transduction cascades and their complex regulation and cross-talk with other intracellular signaling pathways that impact on cell survival. Upon reviewing the text, the reader is

Overview

Through use of this text, the reader is educated about the death ligands, death receptor pathways and their alterations in human cancer. The reader will learn about novel emerging signal transduction cascades and their complex regulation and cross-talk with other intracellular signaling pathways that impact on cell survival. Upon reviewing the text, the reader is exposed to current thinking about the role of death ligands and death receptors in-vivo, with respect to tumor suppression and important aspects of the immune response. In closing, the editors explain strategies for the use of death receptor pathways to develop diagnostic and therapeutic strategies for cancer.

Product Details

ISBN-13:
9781588291721
Publisher:
Springer-Verlag New York, LLC
Publication date:
12/14/2009
Series:
Cancer Drug Discovery and Development Series
Edition description:
2005
Pages:
374
Product dimensions:
7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Mammalian Cell Death Pathways: Intrinsic and Extrinsic

E. Robert McDonald III and Wafik S. El-Deiry

Resistance to Apoptosis in Cancer Therapy

David J. McConkey

Structures of TNF Receptors and Their Interactions With Ligands

Sarah G. Hymowitz and Abraham M. de Vos

Death Receptor Signaling in Embryonic Ectodermal Development

Preet M. Chaudhary

Adaptor Proteins in Death Receptor Signaling

Nien-Jung Chen and Wen-Chen Yeh

Caspase Activation by the Extrinsic Pathway

Xiaolu Yang

Death Signaling and Therapeutic Applications of TRAIL

Mi-Hyang Kim and Dai-Wu Seol

Death Receptor Mutations

Sug Hyung Lee, Nam Jin Yoo, and Jung Young Lee

Regulation of Death Receptors

Udo Kontny and Heinrich Kovar

Regulation of TRAIL Receptor Expression in Human Melanoma

Peter Hersey, Si Yi Zhang, and Xu Dong Zhang

Regulation of Death Receptors by Synthetic Retinoids

Shi-Yong Sun

Role of p53 in Regulation of Death Receptors

Rishu Takimoto

Proapoptotic Gene Silencing Via Methylation in Human Tumors

Tanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. Kidd

Regulation of Death Receptor-Induced Apoptosis by NF-kB and Interferon Signaling Pathways: Implications for Cancer Therapy

Rajani Ravi and Atul Bedi

TRAIL in Cancer Therapy

Mahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz Rehemtulla

Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma

Subrata Ray, John G. Hissong, Marcela Oancea, and Alex Almasan

Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors

Rüdiger Göke and Youhai H. Chen

Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors

Christina Voelkel-Johnson

Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer

James S. Norris, David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid, and Yusuf Hannun

Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers

Lidong Zhang and Bingliang Fang

Combination of Chemotherapy and Death Ligands in Cancer Therapy

Simone Fulda and Klaus-Michael Debatin

Index

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