Death Receptors in Cancer Therapy / Edition 1

Death Receptors in Cancer Therapy / Edition 1

by Wafik S. El-Deiry
     
 

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ISBN-10: 1617374016

ISBN-13: 9781617374012

Pub. Date: 11/19/2010

Publisher: Springer-Verlag New York, LLC

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the

Overview

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Product Details

ISBN-13:
9781617374012
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/19/2010
Series:
Cancer Drug Discovery and Development Series
Edition description:
Softcover reprint of hardcover 1st ed. 2005
Pages:
374
Product dimensions:
7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Mammalian Cell Death Pathways: Intrinsic and Extrinsic

E. Robert McDonald III and Wafik S. El-Deiry

Resistance to Apoptosis in Cancer Therapy

David J. McConkey

Structures of TNF Receptors and Their Interactions With Ligands

Sarah G. Hymowitz and Abraham M. de Vos

Death Receptor Signaling in Embryonic Ectodermal Development

Preet M. Chaudhary

Adaptor Proteins in Death Receptor Signaling

Nien-Jung Chen and Wen-Chen Yeh

Caspase Activation by the Extrinsic Pathway

Xiaolu Yang

Death Signaling and Therapeutic Applications of TRAIL

Mi-Hyang Kim and Dai-Wu Seol

Death Receptor Mutations

Sug Hyung Lee, Nam Jin Yoo, and Jung Young Lee

Regulation of Death Receptors

Udo Kontny and Heinrich Kovar

Regulation of TRAIL Receptor Expression in Human Melanoma

Peter Hersey, Si Yi Zhang, and Xu Dong Zhang

Regulation of Death Receptors by Synthetic Retinoids

Shi-Yong Sun

Role of p53 in Regulation of Death Receptors

Rishu Takimoto

Proapoptotic Gene Silencing Via Methylation in Human Tumors

Tanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. Kidd

Regulation of Death Receptor-Induced Apoptosis by NF-kB and Interferon Signaling Pathways: Implications for Cancer Therapy

Rajani Ravi and Atul Bedi

TRAIL in Cancer Therapy

Mahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz Rehemtulla

Expression and Regulation of Death Receptors in Multiple Myeloma and Prostate Carcinoma

Subrata Ray, John G. Hissong, Marcela Oancea, and Alex Almasan

Regulation of TRAIL-Induced Apoptosis by Transcriptional Factors

Rüdiger Göke and Youhai H. Chen

Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors

Christina Voelkel-Johnson

Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer

James S. Norris, David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid, and Yusuf Hannun

Gene Therapy Targeting Receptor-Mediated Cell Death to Cancers

Lidong Zhang and Bingliang Fang

Combination of Chemotherapy and Death Ligands in Cancer Therapy

Simone Fulda and Klaus-Michael Debatin

Index

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