A Decade of HAART: The Development and Global Impact of Highly Active Antiretroviral Therapy

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Highly active antiretroviral therapy (HAART) is a therapeutic intervention developed by clinicians and researchers in order to fight the HIV pandemic. It has contributed to a significant reduction in AIDS-related mortality and allowed many previously bed-ridden patients to live healthier, more productive lives. Until the advent of HAART in 1996, a diagnosis of HIV infection was considered a death sentence. A decade later, the disease has been transformed into a serious, yet potentially manageable, medical condition for thousands of people living with HIV/AIDS in the developed world - almost overnight creating a generation of "HIV Survivors" - and forged a global movement to ensure that its Lazarus-like benefit reaches millions more in the developing world. This book reviews the achievements of HAART over the past decade, and explores the challenges that may arise in the future. It recounts key landmarks in the development and introduction of HAART from the perspective of clinicians, researchers, economists, sociologists, and public policy experts, including the co-discoverers of HIV, Luc Montagnier and Robert Gallo. It explores the evolution of the disease, the evolution of HIV treatment, and the economic, social, and public policy impacts of both HIV and the introduction of HAART.

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Editorial Reviews

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"...this book provides a fascinating and accessible account of the first decade of HAART and of 25 years of HIV infection that will be of interest to many."—Clinical Infectious Diseases
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Product Details

  • ISBN-13: 9780199225859
  • Publisher: Oxford University Press, USA
  • Publication date: 12/15/2008
  • Edition description: New Edition
  • Pages: 464
  • Product dimensions: 7.00 (w) x 9.80 (h) x 1.30 (d)

Table of Contents

List of Contributors xiii

List of Figures xvii

List of Tables xxi

List of Acronyms and Abbreviations xxiii

Part 1 A decade of HAART: trials, tribulations and successes

1 Introduction Jose M. Zuniga Alan Whiteside Amin Ghaziani John G. Bartlett 3

2 A world ravaged by a disease without HAART Jose M. Zuniga Amin Ghaziani 7

3 Turning the world on its ear: defining milestones on the road to HAART Michel D. Kazatchkine Lieve Fransen 35

4 The outcome and impact of 10 years of HAART Eduard J. Beck Rochelle P. Walensky 45

5 HAART in HIV-infected children: one decade later Arry Dieudonne James A. McIntyre Federica Fregonese Carlo Giaquinto James M. Oleske 63

Part 2 HAART in high human development countries

6 Country review: Australia Kathleen Glenday Kathy Petoumenos Matthew G. Law David A. Cooper 85

7 Country review: Chile Marcelo J. Wolff 103

8 Country review: Germany Eva Wolf Hans Jaeger 119

9 Country review: Italy Renato Maserati 137

10 Country review: United States of America Renslow Sherer 151

11 US Cohorts review: The HIV Outpatient Study (HOPS) and the Multicenter AIDS Cohort Study (MACS) Frank J. Palella, Jr Anne C. Moorman John T. Brooks John Phair Lisa Jacobson Roger Detels Joseph Margolick Charles Rinaldo 171

12 The French Hospital Database on HIV (FHDH) ANRS CO4 Dominique Costagliola 185

13 EuroSIDA: a prospective observational study of chronic HIV infection across the European continent Jens D. Lundgren Ole Kirk Amanda Mocroft 195

14 The Swiss HIV Cohort Study (SHCS) Huldrych F Gunthard Bernard Hirschel 213

15 The OPTIMA Cohort Mark Holodniy 219

Part 3 HAART in medium human development countries

16Country review: Brazil Celso Ferreira Ramos-Filho Cledy Eliana dos Santos 241

17 Country review: China Zhang Fu-Jie Ray Y. Chen Selina N. Lo Ma Ye 253

18 Country review: South Africa Robin Wood Des Martin 275

19 Country review: Thailand Praphan Phanuphak Sanchai Chasombat Jintanat Ananworanich 291

20 Cohort studies in Brazil: Projeto Praca Onze Mauro Schechter Suely Hiromi Tuboi 311

21 The HIV Netherlands-Australia-Thailand research collaboration (HIV-NAT) Kiat Ruxrungtham 329

Part 4 HAART in low human development countries

22 Country review: Haiti Serena Koenig Julia Carney Peter Bendix Jean William Pape 359

23 Country review: Malawi Erik J. Schouten Simon D. Makombe Anthony D. Harries Kelita Kamoto 379

24 Country review: Senegal Papa Salif Sow 395

25 Country review: Zambia Moses Sinkala Benjamin H. Chi 403

Part 5 Future challenges in the next decade of HAART

26 The clinical challenges of lifetime HAART Roger Paredes Renslow Sherer Bonaventura Clotet 421

27 Maintaining and developing health systems to sustain HAART Stephanie Nixon Nina Veenstra 463

28 Redefining HIV/AIDS care delivery in the face of human resource scarcity Mario Roberto Dal Poz Norbert Dreesch Dingie van Rensburg 477

29 Closing the gap in the next decade of HAART: one world, one standard Peter Piot Julian Fleet Siddharth Dube 497

Index 509

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