Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease / Edition 1by Rudolph E. Tanzi
Pub. Date: 12/28/2001
Publisher: Basic Books
Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein -- beta amyloid -- Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the revolution that propels it, the obstacles that threaten to derail it, and the families whose lives are so dependent upon it.
- Basic Books
- Publication date:
- Edition description:
- New Edition
Table of Contents
|1||Cleave, Zap, Blot, Probe||1|
|2||The Core of the Matter||21|
|6||From Famine to Feast||99|
|8||Of Mice and People||135|
|10||The 42 Nidus||173|
|11||Untangling a Cascade||191|
|12||A Gamble for Hope||207|
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >
This book presents an absolutely fascinating account of Alzheimer's disease research. The authors deliver a very balanced account of Alzheimer's disease gene research giving ample coverage and credit to dozens of worthy scientists working on this terrible disease. This was a great and exciting read--highly recommended!
After reading about Dr. Tanzi in the book Hard to Forget and seeing him profiled on tv, I was really expecting a fascinating book. But this book is a big disappointment. At times this seems like a pr piece for Dr. Tanzi, with so much focus on his awards and how important his research is. There's not much humility or dark night of the scientific soul here. I liked Daniel Pollen's Hannah's Heirs, which another reviewer has mentioned -- even though the writing isn't first rate in that book, either, it seems more objective and therefore a 'truer' story. As for this book, all I can say is that it's much more interesting to read something about Dr. Tanzi than it is to read something written by him!
Decoding Darkness is a riveting read. A lay person not familiar with medicine can enjoy this book as well as the most educated doctor. It is brilliantly written by Dr. Tanzi who shows humor and compassion throughout the book. It tells of the fascinating journey from the early days of Tanzi's research to the present day, the changes, the discoveries and the disappointments. The book gives you an inside view of this horrific disease and its traumatic effects on not only the patient, but the family too. It is a must read by anyone who has been touched by this disease and those who have been lucky enough to escape it.
Once I started reading Decoding Darkness, it was difficult to put down. I found the book to be a very intriguing story of a scientist who apparently is dedicating his life to finding the cause and cure of Alzheimer's Disease. Dr. Tanzi wrote and Ann Parson's narrated this book in such a way that it held my interest from cover to cover. It was written with a vast amount of information, but easy to understand and with a great deal of humor. I suggest this book for any family who has been afflicted with Alzheimer's and everyone who has a human interest in the curing of diseases and of the people who dedicate their lives to these causes.
This fascinating account transports the reader to the front lines of Alzheimer's disease research. This book brings the reader on a insightful, humorous, and poignant journey from the early days of AD research to the current, where drugs to treat this disease seem close at hand. Like so many others, my family knows the horrors of this disease and are so thankful to AD researchers like Dr. Tanzi who have devoted their lives to unraveling this disease. I found this personal tale very engaging and I have recommended to family and friends.