Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease / Edition 1

Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease / Edition 1

4.4 5
by Rudolph E. Tanzi
     
 

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ISBN-10: 0738205265

ISBN-13: 2900738205266

Pub. Date: 12/28/2001

Publisher: Basic Books

Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein -- beta amyloid -- Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the

Overview

Working from the intriguing hypothesis that Alzheimer's dementia is the result of a renegade protein -- beta amyloid -- Tanzi and others set out to find the gene responsible for its production. Decoding Darkness takes us deep into the minds and far-flung labs of many a prominent researcher, offering an intimate view of the high stakes of molecular genetics, the revolution that propels it, the obstacles that threaten to derail it, and the families whose lives are so dependent upon it.

Product Details

ISBN-13:
2900738205266
Publisher:
Basic Books
Publication date:
12/28/2001
Edition description:
New Edition
Pages:
304

Table of Contents

Introductionxiii
1Cleave, Zap, Blot, Probe1
2The Core of the Matter21
3Candidate Chromosome49
4Gone Fishing61
5Curious Gene85
6From Famine to Feast99
7Mutations, Revelations115
8Of Mice and People135
9Gene Prix147
10The 42 Nidus173
11Untangling a Cascade191
12A Gamble for Hope207
Epilogue241
Resources249
Notes251
Index269

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Decoding Darkness: The Search for the Genetic Causes of Alzheimer's Disease 4.4 out of 5 based on 0 ratings. 5 reviews.
Guest More than 1 year ago
This book presents an absolutely fascinating account of Alzheimer's disease research. The authors deliver a very balanced account of Alzheimer's disease gene research giving ample coverage and credit to dozens of worthy scientists working on this terrible disease. This was a great and exciting read--highly recommended!
Guest More than 1 year ago
After reading about Dr. Tanzi in the book Hard to Forget and seeing him profiled on tv, I was really expecting a fascinating book. But this book is a big disappointment. At times this seems like a pr piece for Dr. Tanzi, with so much focus on his awards and how important his research is. There's not much humility or dark night of the scientific soul here. I liked Daniel Pollen's Hannah's Heirs, which another reviewer has mentioned -- even though the writing isn't first rate in that book, either, it seems more objective and therefore a 'truer' story. As for this book, all I can say is that it's much more interesting to read something about Dr. Tanzi than it is to read something written by him!
Guest More than 1 year ago
Decoding Darkness is a riveting read. A lay person not familiar with medicine can enjoy this book as well as the most educated doctor. It is brilliantly written by Dr. Tanzi who shows humor and compassion throughout the book. It tells of the fascinating journey from the early days of Tanzi's research to the present day, the changes, the discoveries and the disappointments. The book gives you an inside view of this horrific disease and its traumatic effects on not only the patient, but the family too. It is a must read by anyone who has been touched by this disease and those who have been lucky enough to escape it.
Guest More than 1 year ago
Once I started reading Decoding Darkness, it was difficult to put down. I found the book to be a very intriguing story of a scientist who apparently is dedicating his life to finding the cause and cure of Alzheimer's Disease. Dr. Tanzi wrote and Ann Parson's narrated this book in such a way that it held my interest from cover to cover. It was written with a vast amount of information, but easy to understand and with a great deal of humor. I suggest this book for any family who has been afflicted with Alzheimer's and everyone who has a human interest in the curing of diseases and of the people who dedicate their lives to these causes.
Guest More than 1 year ago
This fascinating account transports the reader to the front lines of Alzheimer's disease research. This book brings the reader on a insightful, humorous, and poignant journey from the early days of AD research to the current, where drugs to treat this disease seem close at hand. Like so many others, my family knows the horrors of this disease and are so thankful to AD researchers like Dr. Tanzi who have devoted their lives to unraveling this disease. I found this personal tale very engaging and I have recommended to family and friends.